Integrative research agenda for diagnosis in sepsis

Intensive care medicine deals with the most critically and time-sensitive patients in the hospital. Each patient requires individualised point-of-care (POC) management and continuous care. In recent years high rates of sepsis and septic shock in intensive care unit (ICU) medicine have become omni-present. Sepsis is a severe systemic inflammatory response in which the host response to infection causes organ dysfunction and raises mortality risk. The time-sensitive nature of sepsis is exacerbated by the variable nature of presentation and a lack of medical consensus on diagnostic parameters.