Progressive nature of myocardial fibrosis in pediatric hypertrophic cardiomyopathy: from mutation carrier to myocardial fibrosis

Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy found in adults (1). Due to a wide variety of genetic defects and penetration, phenotypic manifestations or symptoms rise to the surface at a different time point during the lifetime (2). Early studies in adult HCM population focused on clinical manifestation and prognosis of patients with overt left ventricular hypertrophy (LVH).