Testosterone replacement in androgen insensitivity: is there an advantage?

Androgen insensitivity syndrome (AIS) is the most common etiology of 46,XY disorders of sex development (DSD) (1). In the complete phenotype (CAIS), affected individuals present typically female external genitalia at birth, are assigned as female and present psychosexual development in agreement with sex assignment (2). In CAIS, bilateral gonadectomy is necessary either due to inguinal hernia at childhood or to avoid germ cell tumor development (3).