UICC and AJCC 8th edition tumor-nodes-metastasis (TNM) classifications for patients treated with radical prostatectomy: reliable but not infallible prognostic tools

We read with interest the article by Herden and colleagues (1) regarding the validation of the UICC and AJCC 8^th edition tumor-nodes-metastasis (TNM) system on a German community-based dataset. In this study, the authors analyzed data derived from the HAROW study (n=2,957), a prospective, non-interventional, health service research study examining various treatment options for patients with localized prostate cancer (≤ cT2c).