Inflammatory lymphadenopathy in renal cell carcinoma: prognostic tool?

Significant lymphadenopathy in renal cell carcinoma (RCC) is often considered an important poor prognostic factor (1). A recent study by Muttin et al. (2) published in the World Journal of Urology attempts to refute this notion. As a pathologist, I am mighty pleased when he concludes that “a radiological suspicion of nodal metastases should not be considered as a poor prognostic factor, at least not until confirmation of nodal involvement at final pathology”.