Reply to “Is the Guytonian framework justified in explaining heart lung interactions?” and “Venous return, mean systemic pressure and getting the right answer for the wrong reason”

We thank Dr. Dalmau and Prof. Brengelmann for their interest in our review article on the determinants of venous return (VR) during positive pressure ventilation (1). In this review, we have tried to give a balanced view on the topic, including all aspects of a long-lasting debate.