Do hypofraction and large breast size reciprocally fit in breast cancer radiotherapy?

At present, postoperative whole breast irradiation (WBI) is standard of care for early-stage breast cancer patients (EBC) after breast conserving surgery (BCS), leading to a reduction in terms of both ‘any breast cancer recurrence’ and ‘breast-cancer mortality’ (1,2). With respect to fractionation, hypofractionated WBI has been tested within 4 prospective randomised controlled trials, reporting robust and reliable long-term local control and survival, toxicity profile and cosmetic outcome (3).