Management of brain metastases from renal cell carcinoma

The most common primary tumors associated with brain metastases are lung (20–56%), melanoma (6–11%), breast (5–30%), and renal cell carcinoma (RCC) (2–7%) (1,2). However, the true incidence is likely higher than these estimates because most guidelines for solid tumors do not recommend routine brain magnetic resonance imaging (MRI) screening in patients without neurological symptoms. Recent clinical trial enrolments often involve a concomitant requirement for brain MRI screening.