Initiation of renal replacement therapy in patients with septic acute kidney injury: right timing or right patient?

We thank Dr. Zhang and Uhel et al. for their interest in our study IDEAL-ICU (1) and appreciate their pertinent comments (2,3). Indeed, from two different points of view, they draw an accurate and synthetic overview of the state of knowledge on the timing of renal replacement therapy (RRT) for acute kidney injury (AKI) in intensive care unit (ICU) patients. However, we only partially agree with their conclusions.