SABR-COMET: a new paradigm of care lights up the twilight of metastatic disease

Not so long ago, the diagnosis of haematogenous metastases in a patient with a solid organ malignancy was synonymous with incurability and palliation. It was assumed that the appearance of the metastatic phenotype, even if at only one site, was the tip of the iceberg, and that it would only be a matter of time before synchronous but microscopic deposits would become clinically evident macroscopic metastases.