Is dyschloremia a marker of critical illness or euchloremia an interventional target to improve outcomes?

Despite chloride being the most abundant extracellular anion, its significance in clinical practice was undervalued for years. In the past decade this has dramatically changed to the point of chloride receiving the distinction of “queen” of electrolytes (1); with several observational and interventional studies focused on the chloride content of crystalloid solutions used for fluid resuscitation.