It is time to integrate conventional therapy by ozone therapy in type-2 diabetes patients

We read the article written by Gregg et al. [2014] (1). It is an excellent paper and describes that rates of type-2 diabetes related complications have deeply declined during the last fifteen years in spite of a tripled increase of the number of diabetic patients. The reduction of acute myocardial infarction, stroke, amputation and end-stage renal disease are certainly due to an improved clinical care, performance of the healthcare system, and patient education in disease management. A far more effective glycemic control, the use of statins as well as coronary revascularization have been the most critical factors but nonetheless acute myocardial infarction, death from hyperglycemia, stroke and amputation the frequency of which halved remain the most stubborn affections dominated by a chronic oxidative stress. This is due to an increased production of reactive oxygen species (ROS), a decreased GSH synthesis, a decreased antioxidant system, production of phase 2 enzymes and HO-1 incapable of neutralizing the excess of oxidants (2).