Highlighted Reports in Galectins


Galectins as therapeutic targets for hematological malignancies: a hopeful sweetness

Camilo Pena, Leonardo Mirandola, Jose A. Figueroa, Nattamol Hosiriluck, Natallia Suvorava, Kayley Trotter, Adair Reidy, Rahman Rakhshanda, Drew Payne, Marjorie Jenkins, Fabio Grizzi, Lauren Littlefield, Maurizio Chiriva-Internati, Everardo Cobos

Abstract

Galectins are family of galactose-binding proteins known to play critical roles in inflammation and neoplastic progression. Galectins facilitate the growth and survival of neoplastic cells by regulating their cross-talk with the extracellular microenvironment and hampering anti-neoplastic immunity. Here, we review the role of galectins in the biology of hematological malignancies and their promise as potential therapeutic agents in these diseases.

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