New therapies for reducing post-myocardial left ventricular remodeling

Current therapies for myocardial infarction are geared to try to limit ischemic/reperfusion injury by early and complete reperfusion, including percutaneous coronary interventions, antiplatelet agents, and anticoagulants; and attempts to limit post infarction left ventricular remodeling by inhibitors of the renin-angiotensin-aldosterone pathway or administration of beta blockers. Despite wide use of these therapies, 30-day mortality still runs 7-8% and one year mortality runs around 23% (1).