Original Article
Risk of coronary artery disease in patients with ankylosing spondylitis: a systematic review and meta-analysis
Abstract
Objective: To investigate the association between coronary artery disease (CAD) and ankylosing spondylitis (AS).
Methods: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, standardized prevalence ratio or standardized incidence ratios with 95% confidence comparing CAD risk in patients with AS versus non-AS controls. Pooled risk ratios and 95% confidence intervals (CI’s) were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.
Results: Out of 229 potentially relevant articles, ten studies (five retrospective cohort studies and five cross-sectional studies) were identified and included in our data analysis. The overall pooled risk ratio of CAD in patients with AS was 1.41 (95% CI: 1.29-1.54). The pooled risk ratios for cross-sectional and cohort studies were 2.08 (95% CI: 1.28-3.40) and 1.36 (95% CI: 1.31-1.41), respectively. The statistical heterogeneity of this meta-analysis was moderate with an I2 of 56%.
Conclusions: Our study demonstrated a statistically significant increased CAD risk among patients with AS with 41% excess risk.
Methods: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, standardized prevalence ratio or standardized incidence ratios with 95% confidence comparing CAD risk in patients with AS versus non-AS controls. Pooled risk ratios and 95% confidence intervals (CI’s) were calculated using a random-effect, generic inverse variance of DerSimonian and Laird.
Results: Out of 229 potentially relevant articles, ten studies (five retrospective cohort studies and five cross-sectional studies) were identified and included in our data analysis. The overall pooled risk ratio of CAD in patients with AS was 1.41 (95% CI: 1.29-1.54). The pooled risk ratios for cross-sectional and cohort studies were 2.08 (95% CI: 1.28-3.40) and 1.36 (95% CI: 1.31-1.41), respectively. The statistical heterogeneity of this meta-analysis was moderate with an I2 of 56%.
Conclusions: Our study demonstrated a statistically significant increased CAD risk among patients with AS with 41% excess risk.
