Achieving tissue specific levels of angiogenesis: Not(ch) a big deal!

Our understanding of the molecular mechanisms regulating endothelial cell behavior in bone vs. other organs has been challenging to date given the inaccessibility of blood vessels deep within the bone mineral and the difficulties associated with bone endothelial cell isolation. A recent study published by Ramasamy et al., combined postnatal modification of endothelial cell specific Notch signals with improved immunohistochemical approaches and bone endothelial cell isolation, to highlight for the first time the presence of clear bone endothelial cell heterogeneity.