AB104. Glucose-6 phospate dehydrogenase deficiency among mongolian neonates
Part 4: Oral/poster

AB104. Glucose-6 phospate dehydrogenase deficiency among mongolian neonates

Khishigjargal Batjargal1, Gerelmaa Nansal2, Gerelmaa Zagd1, Erdenetuya Ganbaatar3

1Department of Pediatrics, School, of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; 2National Centre for Maternal and Child Health, Ulaanbaatar, Mongolia; 3Newborn Screening Center and Department of Pediatrics, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

Background and objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in humans, affecting 400 million people worldwide and a high prevalence in persons of African, Middle Asian countries. The most common clinical manifestations are neonatal jaundice and acute hemolytic anemia, which is caused by the impairment of erythrocyte’s ability to remove harmful oxidative stress triggered by exogenous agents such as drugs, infection, or fava bean ingestion. Neonatal hyperbilirubinemia caused by G6PD is strongly associated with mortality and long-term neurodevelopmental impairment. The study aims to determine a level of G6PD in healthy neonates.

Methods: We obtained blood spot samples from 268 infants around 24-72 hours in their age who has unsuspected intranatal and neonatal disorders. Glucose 6 phosphate dehydrogenase “Perkin Elmer, Finland” level is determined by Victor 2D Fluorometer assay, developing of neonatal jaundice is examined by recall.

Results: The76.5% of all participants (n=205) was assessed 4.36±1.15 Ug/Hb in normal reference range of G6PD, other 23.5% (n=63) was 0.96±0.51 Ug/Hb with G6PD deficiency. In the both sex, 51.5% of male 0.88±0.46 Ug/Hb (n=33) and 47.6% of female (n=30) 0.97±0.55 Ug/Hb was assessed with G6PD deficiency. Developing Jaundice period in number of 63 neonates with G6PD deficiency, 86% of neonates (n=54) was in 1-4 days, 4% of neonates (n=3) was in 5-7 days and there is no sign of jaundice in 9% (n=6). Therefore neonates with G6PD deficiency, 53.9% (n=34) continued jaundice more than two weeks.

Conclusions: G6PD deficiency was determined in male neonates (51.5%) more than female (47.6%). The 76.5% of all participants (n=205) was assessed 4.36±1.15 Ug/Hb in normal reference range of G6PDH other 23.5% (n=63) of all participants was 0.96±0.51 Ug/Hb with G6PD deficiency. It shows that G6PD might be one potential risk of neonatal jaundice and hyperbilirubinemia in neonates in Mongolia.

Keywords: Neonatal jaundice; enzyme deficiency; newborn screening; neonatal hemolysis

Cite this abstract as: Batjargal K, Nansal G, Zagd G, Ganbaatar E. Glucose-6 phospate dehydrogenase deficiency among mongolian neonates. Ann Transl Med 2015;3(S2):AB104. doi: 10.3978/j.issn.2305-5839.2015.AB104

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