Risk factors of continuous renal replacement therapy following total aortic arch replacement under moderate hypothermia
Original Article

Risk factors of continuous renal replacement therapy following total aortic arch replacement under moderate hypothermia

Bo Li1#, Qing-Liang Chen1#, Bo-Chen Yao1, Nan Jiang1, Feng Zhao1, Min Ren2, Jing Sun1, Li-Na Xu1, Zhi-Gang Guo1

1Department of Cardiovascular Surgery, Tianjin Chest Hospital, Tianjin, China; 2Tianjin Institute of Cardiovascular Diseases, Tianjin, China

Contributions: (I) Conception and design: All authors; (II) Administrative support: M Ren, N Jiang, F Zhao, LN Xu, ZG Guo; (III) Provision of study materials or patients: B Li, QL Chen, BC Yao; (IV) Collection and assembly of data: B Li, QL Chen, BC Yao; (V) Data analysis and interpretation: B Li, QL Chen, BC Yao, M Ren; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

#These authors contributed equally to this work.

Correspondence to: Qing-Liang Chen. Department of Cardiovascular Surgery, Tianjin Chest Hospital, 261 Taierzhuang Road, Tianjin 300001, China. Email: 314067280@qq.com; Zhi-Gang Guo. Tianjin Chest Hospital, 261 Taierzhuang Road, Tianjin 300001, China. Email: docboblee86@gmail.com.

Background: Stanford type A aortic dissection (TAAD) has a sudden onset and high mortality, and emergency total aortic arch replacement (TAAR) is the main treatment option for TAAD. The mortality rate of patients with postoperative acute kidney injury (AKI) combined with continuous renal replacement therapy (CRRT) is remarkable higher than that of patients without AKI. However, incidence of AKI and risk factors for CRRT following TAAR isn’t entirely understood.

Methods: From October 2018 to March 2021, all patients with Stanford type A dissection who underwent total arch replacement surgery under MHCA were enrolled. According to whether CRRT treatment was performed, participants were divided into a CRRT group (n=49) and control group (n=72). Both groups incorporated the brain protection strategy of moderate hypothermia, and the left common carotid artery and the innominate artery were perfused anteriorly. Relevant medical data was collected.

Results: Age, gender, and a history of smoking and drinking were not significantly different between the 2 groups (P>0.1). There were statistical differences between the 2 groups in aortic sinus diameter and Bentall procedure (P≤0.05). Univariate analysis revealed that fresh frozen plasma was a protective factor (P<0.05) and the intraoperative transfusion volume of red blood cells, platelets, fresh frozen plasma, autologous blood used for intraoperative bleeding, aortic sinus diameter, and Bentall procedure were risk factors (P<0.1). Multivariate analysis showed that the Bentall procedure and intraoperative bleeding were risk factors for CRRT (P<0.05), and the aortic sinus diameter and intraoperative transfusion score were also risk factors for CRRT (P<0.05). Receiver operating characteristic (ROC) analysis demonstrated that the model of aortic sinus diameter and intraoperative transfusion score had more significantly different discriminatory powers.

Conclusions: The Bentall procedure, intraoperative bleeding, aortic sinus diameter, and intraoperative transfusion score were risk factors for postoperative CRRT. The model of aortic sinus diameter and intraoperative transfusion score had more significantly different discriminatory powers.

Keywords: Acute kidney injury (AKI); continuous renal replacement therapy (CRRT); moderate hypothermia circulatory arrest (MHCA); type A aortic dissection (TAAD); total aortic arch replacement (TAAR)


Submitted Jul 19, 2021. Accepted for publication Aug 30, 2021.

doi: 10.21037/atm-21-3905


Introduction

Stanford type A aortic dissection (TAAD) is characterized by a sudden onset and high mortality (1). Currently, total aortic arch replacement (TAAR) is routinely performed using deep hypothermic circulatory arrest (DHCA) for the treatment of TAAD (2). However, the operative long-term use of DHCA damages multiple organs. Acute kidney injury (AKI), occurs in approximately 40–50% of patients after aortic surgery using DHCA (3). Approximately 6% of patients with AKI require continuous renal replacement therapy (CRRT).

In recent years, surgical treatment of type A aortic dissection (TAAD) has been performed using moderate hypothermia hypothermic circulatory arrest (MHCA) in many medical centers to reduce the incidence of postoperative complications (4,5). However, AKI still occasionally occurs, and the incidence of AKI and risk factors for CRRT following TAAR under moderate hypothermia have rarely been reported. This single-center study retrospectively analyzed 121 patients with TAAD undergoing TAAR using MHCA and discusses the incidence of AKI and risk factors for CRRT following TAAD, with an aim to protect postoperative renal function and improve clinical outcomes. We present the following article in accordance with the STROBE reporting checklist (available at https://dx.doi.org/10.21037/atm-21-3905).


Methods

General data

All patients with TAAD who underwent TAAR using MHCA at this center from October 2018 to March 2021 were considered potential participants. Among them, those with acute aortic dissection undergoing surgical treatment 3 d after the onset were included in this study. Patients were excluded based on the exclusion criteria, as follows: (I) TAAD involved the renal artery, or a history of acute or chronic renal insufficiency with/without elevated creatinine levels; (II) preoperative pericardial tamponade affecting hemodynamic stability and requiring maintenance of circulation by vasoactive agents; (III) TAAD involved the iliac artery, resulting in cool skin temperature of the lower extremities, a weakened pulse, significantly elevated myoglobin levels, and postoperative ischemia-reperfusion injury. Finally, a total of 121 patients were included. All participants underwent computed tomography angiography (CTA) of the aorta and echocardiography to identify the extent of diagnosis and lesion and the involvement of the coronary artery (Table 1). The study was approved by Institutional Ethics Review Board of Tianjin Chest Hospital (2018-2123), and individual consent for this retrospective analysis was waived. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013).

Table 1

Preoperative variables

Variable Control group CRRT group T-value or χ2 value P value
Gender (M/F, n) 48/24 35/14 0.31 0.58
Age (year) 57.2±10.2 56.6±12.6 –0.27 0.79
Smoking, n (%) 38 (52.8) 27 (55.1) 0.06 0.80
Drinking, n (%) 22 (30.6) 12 (24.5) 0.53 0.47
Complications, n (%)
   Hypertension 55 (76.4) 39 (79.6) 0.17 0.68
   Diabetes 2 (2.8) 0 (0.0) 1.38 0.24
   Cerebrovascular accident 4 (0.0) 2 (2.8) 0.13 0.71
   Coronary heart disease 8 (16.3) 8 (11.1) 0.69 0.41
Echocardiography measurements
   Aortic sinus diameter (mm) 42.2±6.8 45.3±6.8 0.50 0.05
   Ascending aorta diameter (mm) 47.2±7.1 46.9±6.6 –0.20 0.84
   LAEDD (mm) 36.9±4.4 36.1±6.1 –0.76 0.45
   LVEDD (mm) 52.6±6.2 52.4±7.8 –0.15 0.88
   LVEF (mm) 56.0±5.0 54.9±7.5 –0.85 0.40
   Mitral valvular lesion, n (%) 8 (11.1) 3 (6.1) 0.88 0.35
   Aortic valvular lesions, n (%) 27 (37.5) 25 (51.0) 2.18 0.14
Combined surgery, n (%)
   Ascending aorta replacement 39 (54.2) 22 (44.9) 0.31 0.58
   AVR/AVP 7 (9.7) 2 (4.1) 1.09 0.30
   Wheat 3 (4.2) 0 (0.0) 2.09 0.15
   Bentall 12 (16.7) 18 (36.7) 6.30 0.01
   CABG 6 (4.2) 3 (6.1) 0.19 0.66
   MVR 2 (2.8) 0 (0.0) 1.30 0.25

LAEDD, left atrial end-diastolic dimension; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; CRRT, continuous renal replacement therapy; AVR/AVP, aortic valve replacement/aortic valve repair; CABG, coronary artery bypass graft; MVR, mitral valve replacement; CRRT, continuous renal replacement therapy.

Study methods

Criteria of CRRT therapy

The criteria for initiation of CRRT were as follows: (I) patients were admitted to the intensive care unit due to more than 6 h of continuous anuria, and the urine volume was <200 mL for over 10 h; (II) hyperkalemia, when serum potassium concentration >6 mmol/L, marked improvements were not observed in patients routinely treated with diuretics; (III) severe metabolic acidosis (pH <7.2) could also not be improved, and patients showed hemodynamic instability; (IV) serum creatinine (sCr) ≥300 µmol/L; (V) volume overload, with or without pulmonary edema; and poor response to conventional diuretics.

Methods for the implementation of CRRT

A double-channel catheter was placed through percutaneous jugular puncture to establish vascular access. The hemodialysis machine (Prismaflex, Baxter Healthare Corp., Deerfield, IL, USA) and M100 filter (Prismaflex) were used in our center. Most participants were treated using continuous veno-venous hemofiltration (CVVH) mode and we changed the mode according to the different participant conditions. Modified port composition was used in CRRT therapy and pre-dilution and post-dilution at a ratio of 50:50 were adopted. The flow rate of the substitution fluid was 2–4 L/h. Low-molecular-weight heparin was used for anticoagulation, and heparin-free CRRT was administered to participants with coagulopathy.

Surgical method

Participants were placed in a supine position, and they received intravenous and inhalational anesthesia. The procedure was performed through a full median sternotomy and cardiopulmonary bypass (CPB) was established via femoral artery and superior and inferior vena cava cannulation. A left atrial catheter was implanted. The MHCA was performed at 32 °C and the ascending aorta was opened. The thrombus was cleared, the proximal false lumen was eliminated by continuous mattress suture, an artificial blood vessel was implanted, circulatory arrest was confirmed at a rectal temperature of 28 °C, and antegrade selective cerebral perfusion was performed. An open stented graft was deployed into the descending aorta. Subsequently, distal anastomosis was performed between the proximal end of the stent graft and a 4-branched graft. Distal reperfusion began following the completion of proximal anastomosis. The left carotid artery was reconstructed first, then the left subclavian artery, and finally, the innominate artery. Operative variables were shown in Table 2. The simultaneous conduction of other procedures depended on the damage of the aortic root (Table 1).

Table 2

Operative variables

Variable Control group CRRT group T-value or χ2 value P value
CPB and perfusion
   CPB time (min) 177.0±42.4 191.4±53.6 1.64 0.10
   Aortic cross-clamp time (min) 102.4±27.6 107.8±30.9 1.00 0.32
   Circulatory arrest time (min) 15.1±8.7 13.1±11.6 −1.04 0.30
   Cerebral perfusion time (min) 15.1±9.0 14.8±15.4 −0.14 0.89
   Circulatory arrest temperature (anal temperature °C) 27.9±2.3 27.6±1.8 −0.71 0.48
Intraoperative blood product
   Red blood cells (U) 1.1±2.3 2.4±3.4 2.41 0.02
   Platelets (therapeutic dose) 1.1±0.7 1.7±0.8 3.86 0.00
   Fresh frozen plasma (mL) 547.3±383.8 357.7±335.8 −2.70 0.01
   Autologous blood (mL) 950±399.9 1,322.6±810.8 3.33 0.00
Drainage volume
   Intraoperative bleeding (mL) 1,270.0±508.4 1,577.7±824.6 2.47 0.02
   Postoperative drainage (mL) 1,036.6±801.4 1,185.2±923.3 0.91 0.37

CPB, cardiopulmonary bypass; CRRT, continuous renal replacement therapy.

Statistical analysis

The software SPSS 21.0 (IBM Corp., Armonk, NY, USA) was used for statistical analyses. Continuous, normally distributed variables were expressed as mean ± standard deviation (SD), and were compared using Student’s t-test. Categorical variables were compared using Pearson’s χ2 test or Fisher’s exact test as appropriate. Variables with a P<0.1 in univariate analysis were assessed with multivariate analysis using a forward stepwise binary logistic regression model, and a two-sided P value <0.1 was considered statistically significant. Every multivariable model was tested for reliability with the Hosmer-Lemeshow statistic. The scoring indicators were used as inspection variables, and the CRRT treatment was used as the state variable for plotting receiver operator characteristic (ROC) curve. The diagnostic cut-off values were determined using the Youden index. Finally, the discriminatory ability of every logistic regression model developed was tested using the area under ROC curve (AUCROC).


Results

Analysis of general information

In this study, participants were divided into the CRRT (n=49; average age: 56.62±12.6; male: 35, 71.4%) and control (n=72; 57.2±10.2; male: 48, 66.7%) groups depending on whether they accepted CRRT treatment after surgery. Age, gender, and a history of smoking and drinking were not significantly different between the 2 groups (P>0.1). However, the comparison of complications, echocardiography, and concomitant cardiac procedures detected statistical differences between the 2 groups in aortic sinus diameter and Bentall procedure (P≤0.05).

Trend of changes in postoperative sCr levels

On day 1 after surgery, sCr in the CRRT group increased remarkably, with an average value of 214.04±79.51 µmol/L, whereas that in the control group was 127.32±58.08 µmol/L. In the CRRT group, despite the conduction of CRRT treatment, the trend of changes in sCr levels was not obvious on days 2–4 after surgery, and the average value of sCr was 264.20±111.76 µmol/L on day 4 after surgery. In the control group, the sCr levels decreased noticeably within 4 days after surgery, and the average value of sCr was 104.24±76.00 µmol/L on day 4 after surgery (Figure 1).

Figure 1 Changes in postoperative sCr levels. CRRT, continuous renal replacement therapy; sCr, serum creatinine.

Single risk factor analysis of perioperative and intraoperative variables

Comparison of perioperative variables between the 2 groups indicated statistical differences in the intraoperative transfusion volume of red blood cells, platelets, fresh frozen plasma, autologous blood used for intraoperative bleeding, aortic sinus diameter, and Bentall procedure (P<0.1). Univariate analysis found that fresh frozen plasma was a protective factor (P<0.05) and the other variables above were risk factors (P<0.1) (Table 3).

Table 3

Univariate analysis of variables associated with CRRT

Risk factors B-value Wald χ2 value P value OR value 95% CI
Aortic sinus diameter (mm) 0.066 3.729 0.053 1.068 0.999–1.141
Bentall procedure [n (%)] 1.066 6.048 0.014 2.903 1.242–6.788
Red blood cells (U) 0.159 5.120 0.024 1.172 1.022–1.345
Platelets (therapeutic dose) 1.039 12.033 0.001 2.826 1.571–5.083
Fresh frozen plasma (mL) −0.001 6.685 0.010 0.999 0.998–1.000
Autologous blood (mL) 0.001 8.391 0.004 1.001 1.000–1.002
Intraoperative bleeding (mL) 0.001 5.228 0.022 1.001 1.000–1.001
Intraoperative transfusion score 1.239 22.744 0.000 3.452 2.075–5.744

CRRT, continuous renal replacement therapy; OR, odds ratio; CI, confidence interval.

Formulation of intraoperative transfusion score

As the red blood cells, platelets, fresh frozen plasma, and autologous blood used for intraoperative transfusion belonged to the same class of indicators in this study, we formulated intraoperative transfusion scores using cutoff values which were determined by ROC curve. For protective factors, the number “1”/“0” was assigned if transfusion volumes were greater than/less than or equal to the cutoff value. For risk factors, the number “0”/“1” was assigned if transfusion volumes were greater than/less than or equal to the cutoff value (Table 4). The scores in each participant were analyzed, and a univariate analysis was performed. A significant difference between 2 groups was detected in intraoperative transfusion score (P<0.05) (Table 3).

Table 4

Intraoperative transfusion score standard

Assignment Red blood cells (U) Platelets (therapeutic dose) Fresh frozen plasma (mL) Autologous blood (mL)
1 >1.5 >1.5 ≤741.5 >1,375
0 ≤1.5 ≤1.5 >741.5 ≤1,375

Multivariate analysis for CRRT

Correlation analysis revealed a significant correlation between intraoperative bleeding and intraoperative transfusion score (P<0.05). Therefore, multivariate analysis was respectively conducted for the aforementioned two indexes. Table 5 shows that the Bentall procedure and intraoperative bleeding were risk factors for CRRT (P<0.05), and Table 6 shows that the aortic sinus diameter and intraoperative transfusion score were risk factors for CRRT (P<0.1).

Table 5

Multivariate analysis for CRRT [1]

Risk factors B value Wald χ2 value P value OR value 95% CI
Aortic sinus diameter (mm) 0.040 1.139 0.286 1.041 0.967–1.119
Bentall procedure [n (%)] 1.335 5.381 0.020 3.802 1.230–11.750
Intraoperative bleeding (mL) 0.001 7.421 0.006 1.001 1.000–1.002

Hosmer-Lemeshow test χ2=5.592, P=0.693. CRRT, continuous renal replacement therapy; OR, odds ratio; CI, confidence interval.

Table 6

Multivariate analysis for CRRT [2]

Risk factors B value Wald χ2 value P value OR value 95% CI
Aortic sinus diameter (mm) 0.082 3.447 0.063 1.086 0.995–1.185
Bentall procedure [n (%)] 0.881 1.983 0.159 2.413 0.708–8.221
Intraoperative transfusion score 1.345 18.090 0.001 3.839 2.065–7.137

Hosmer-Lemeshow test χ2=12.741, P=0.121. CRRT, continuous renal replacement therapy; OR, odds ratio; CI, confidence interval.

Comparison of precision between 2 models

Analysis of the ROC showed that the 2 models had significantly different discriminatory powers. The results demonstrated a significant improvement in AUC in the model where aortic sinus diameter and intraoperative transfusion score were included (Table 7 and Figure 2).

Table 7

Analysis of the predictive abilities of the 2 models

Model indexes ROC P value 95% CI
Bentall procedure and intraoperative bleeding 0.756 0.000 0.650–0.862
Aortic sinus diameter and Intraoperative transfusion score 0.837 0.000 0.754–0.920

ROC, receiver operating characteristic; CI, confidence interval.

Figure 2 Analysis of the ROC curves for the two models. ROC, receiver operating characteristic.

Discussion

The condition of TAAD has a sudden onset and high mortality (6), and emergency TAAR is the main treatment option for TAAD. Over the years, there has been an increase in the success rate of emergency TAAR and decrease in postoperative mortality, attributable to the fact that MHCA can effectively shorten the duration of cooling and rewarming and reduce postoperative ischemia-reperfusion injury to organs; however, it cannot prevent postoperative complications. The mortality rate (15–30%) of patients with postoperative AKI is 10–20 times that of patients without AKI. Therefore, AKI is an independent risk factor contributing to postoperative death (7). Patients with AKI, especially those with AKI after TAAR procedure, may experience water-sodium retention, azotemia, internal environment disorder, and fluid overload, and should promptly undergo CRRT (8).

In this study, we selected patients undergoing TAAR in this center, and factors that could lead to AKI and those associated with postoperative CRRT were excluded. The potential impact of perioperative indexes on postoperative CRRT was analyzed. After grouping based on whether CRRT was performed, the sCr level in the CRRT group was remarkably higher than that in the control group within 4 days after surgery. To date, the Kidney Disease: Improving Global Outcomes (KDIGO) guideline has been extensively used to determine the optimum time to implement CRRT (9). AKI is defined as: increase in sCr by ≥0.3 mg/dL within 48 hours, increase in sCr to ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days or urine volume <0.5 mL/kg/h for 6 hours. Recently, an increasing number of studies have suggested that earlier implementation of CRRT could lead to better clinical efficacy in treating AKI (10-13). Given the special characteristics of cardiac surgery, there are high requirements for the control of fluid load volume and internal environment within 24 h after surgery, and the time to implement CRRT cannot be determined in accordance with the KDIGO guidelines. In this study, the criteria for CRRT in this center were established based on specific conditions, and compared with the criteria for CRRT used in other cardiac centers, there was no marked difference.

This study revealed that preoperative aortic sinus diameter, combined Bentall procedure, intraoperative blood products, and intraoperative bleeding were risk factors for postoperative CRRT. The aortic sinus diameter was positively correlated with postoperative CRRT, which is believed to be because a greater aortic sinus diameter leads to greater difficulty in vascular anastomosis and a longer surgical duration, thereby causing an increase in the frequency of performing CRRT. A longer surgical duration leads to aggravated destruction of blood constituents and ischemia-reperfusion injury to various organs. Additionally, factors such as surgical trauma can induce systemic inflammatory response syndrome (SIRS) (14) and activate inflammatory factors that induce damage to the vascular endothelium cells upon release, which thereby damages organs and tissues and the renal filtration system when reperfusion occurs. To date, multiple studies have validated that prolonged CPB is also a risk factor. Especially after total aortic arch replacement with DHCA, prolonged CPB and aortic occlusion time were risk factors for acute kidney injury. In this study, CPB duration was not included as a risk factor. This may be attributed to the shortened CPB duration due to MHCA used in TAAR procedure, and as a result, a long CPB duration can be effectively avoided. The Bentall procedure is positively correlated with postoperative CRRT, which primarily involves complicated surgical procedures and prolonged surgical duration.

Intraoperative bleeding and transfusion of blood products are risk factors for postoperative CRRT. Given the difficulty of performing TAAR and long surgical duration, increase in the amount of intraoperative bleeding indicates that more units of banked blood would be transfused during surgery. Therefore, the amount of intraoperative bleeding is closely associated with the quantities of intraoperative blood products transfused. The study findings showed that intraoperative transfusion of red blood cells, platelets, and autologous blood could lead to an increase in the frequency of performing postoperative CRRT, which is consistent with the reports of previous studies (15,16). Regarding the transfusion of a large number of banked red blood cells, platelets, and autologous blood in the surgery, red blood cell fragments, and microthrombus can block the renal tubules, thereby inducing AKI (17). Hemoglobin release by fragmented red blood cells is an important factor contributing to occlusion of the renal tubules. A longer storage of red blood cells leads to reduction in the oxygen delivery capacity and internal milieu regulation capability, leading to the release of cytotoxins, vasoconstriction, and oxidative stress. The aforementioned factors can aggravate AKI (18,19), and their impact is positively correlated with transfusion volume. Intraoperative bleeding also can aggravate intraoperative hemodynamic instability, which can further reduce renal perfusion (20) and induce AKI. In addition, the study findings suggested that the intraoperative use of plasma was negatively correlated with postoperative CRRT, indicating that the use of fresh frozen plasma was a protective factor against AKI. This may be because fresh frozen plasma can effectively maintain stable circulation, and coagulation factors in fresh frozen plasma can strengthen the coagulation function of patients and reduce the consumption of other blood products (21). The specific mechanisms remain to be validated.

The most unique part in my paper is that we formulated intraoperative transfusion scores using cutoff values which were determined by ROC curve. Because we find intraoperative transfusion volume of blood product has a strong relationship with CRRT. But the red blood cells, platelets, fresh frozen plasma, and autologous blood for intraoperative transfusion belong to the same class of indicators in this study. So, this intraoperative transfusion scores can solve the problem that same class data can’t compare with each other. This kind statistic method is not common in other articles. This study had some limitations. It was a single-center trial, surgeon skills and experience, and improvement in surgical procedures significantly affected prognoses. Additionally, the small sample and type II errors inevitably may have led to biased results. Therefore, a future retrospective study with a larger sample size should be performed to reduce such bias. In summary, TAAR takes time and involves complicated surgical procedures. Surgical techniques should be improved in order to reduce intraoperative bleeding and cause minimal damage to blood-formed elements, and indications for intraoperative transfusion should be strictly followed. The surgical duration and CPB time should be maximally shortened, which may be protective against AKI.


Acknowledgments

Funding: This work was supported by Major Projects of Disease Prevention and Cure of Tianjin Science and Technology Commission “Clinical diagnosis and treatment research of elderly patients with aortic dissecting aneurysm in Tianjin” (18ZXDBSY00160).


Footnote

Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://dx.doi.org/10.21037/atm-21-3905

Data Sharing Statement: Available at https://dx.doi.org/10.21037/atm-21-3905

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/atm-21-3905). The authors report that this work was supported by Major Projects of Disease Prevention and Cure of Tianjin Science and Technology Commission (8ZXDBSY00160), payments to Tianjin Chest Hospital. The authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was approved by Institutional Ethics Review Board of Tianjin Chest Hospital (2018-2123), and individual consent for this retrospective analysis was waived. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013).

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


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Cite this article as: Li B, Chen QL, Yao BC, Jiang N, Zhao F, Ren M, Sun J, Xu LN, Guo ZG. Risk factors of continuous renal replacement therapy following total aortic arch replacement under moderate hypothermia. Ann Transl Med 2021;9(18):1448. doi: 10.21037/atm-21-3905

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