Innate immunity and adaptive immunity in Crohn’s disease

Crohn’s Disease (CD) is systemic immune disorder affecting the gastrointestinal tract with frequent extraintestinal manifestations. Generally, CD is considered as a polygenic immune disorder with complex multifactor etiology. Specifically, CD mainly occurs in susceptible individuals in whom upon environmental and commensal microbiota triggers a sustained disturbed mucosal immune reaction. And the chronic unrestrained inflammatory response in CD is mainly driven by a disintegrated host immune regulatory network.