Response to: effect of vasa vasorum in cerebrovascular compensation: 2 case reports

We read with great interest the paper by Wang et al. (1) in a previous issue of Annals of Translational Medicine. The authors report two cases of vasa vasorum (VV) on digital subtraction angiography (DSA) and suggest that VV collaterals would benefit revascularization of previously occluded cerebral arteries with improvement of downstream perfusion. However, their presentations and accompanying angiograms do not provide convincing evidence that the vascular channels developing in chronically occluded arteries are really VV.

First, the so-called VV collaterals penetrating the plaque on DSA may in fact represent luminal recanalization whereby thrombus is replaced by fibrous tissue in the chronic phase. In previous studies (2-4), multiple vascular channels which run distinctly outside of the expected lumen of occluded arteries were generally recognized as bridging collaterals developed from VV. In the process of maturation, the adventitial collaterals grow both in width and length and therefore develop a typical corkscrew-like or bead-like morphology (5,6), which are not consistent with the angiography presented by the authors.

Second, the VV is defined functionally as a network of microvessels that deliver trophic and nutritive factors, as well as regulatory signals. In different stages of atherosclerosis, VV neovascularization may exert both positive and negative physiological effects on plaque stability (7). From this point of view however, improving downstream perfusion is beyond its definition and capacity. Both immature neovascularization leading to local arterial dissection (i.e., inside the vessel wall) and mature neovascularization forming bridging collaterals (i.e., adventitial to the artery wall) are no longer considered VV, but rather the sequelae of local dissection and of bridging collaterals respectively.

Third, the authors comment that DSA could be used prospectively as an approach for observing intracranial VV, which seems extremely unlikely. Literature has extensively documented the approximate range of VV diameters. In coronary arteries, the mean diameter of first-order VV is 160.9±5.10 µm and that of second-order VV is 67.99±2.72 µm (8). However, the detector resolution of contrast angiography is about 250 µm, which makes it impossible to render the genuine contour of VV.

Finally, the authors comment that only contrast agent-enhanced MRI and DSA are feasible modalities for observing intracranial VV. Our article work on a similar topic was published in 2020 and readily reveals first-order VV (9). Using a higher resolution (10 µm) imaging modality, optical coherence tomography, we reported in vivo visualization of the human native intracranial arterial VV and intraplaque neovasculature, as well subsequently this year of neointimal VV with the same technology (10).

Acknowledgments

Funding: This work was supported by the Ministry of Science and Technology of the People’s Republic of China (2016YFC1301701) and the Beijing Scientific and Technologic Project (Z201100005520019).

Footnote

Provenance and Peer Review: This article was a standard submission to the journal. The article did not undergo external peer review.

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-21-855). Dr. LJ reports grants from Ministry of Science and Technology of the People’s Republic of China (2016YFC1301701) and the Beijing Scientific and Technologic Project (Z201100005520019). The other authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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10. Available online: https://www.mdpi.com/2075-4418/11/2/322