Vol 9, No 12 (June 29, 2021): Annals of Translational Medicine

Editorial

Rare variants: data types and analysis strategies
Chayanika Goswami, Amrita Chattopadhyay, Eric Y. Chuang
Annals of Translational Medicine  
2021;
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:961
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 (29 June 2021) 
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Original Article

Efficacy and safety of pulsatile gonadotropin-releasing hormone therapy in patients with congenital hypogonadotropic hypogonadism: a multicentre clinical study
Ming Hao, Jiang-Feng Mao, Qing-Bo Guan, Long Tian, Hu Han, Hong-En Lei, Dong-Mei Zheng, Zhen-Hua Tian, Min Nie, Xi Wang, Bing-Qing Yu, Yin-Jie Gao, Xue-Yan Wu
Annals of Translational Medicine  
2021;
9
(12)
:962
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 (29 June 2021) 
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Cephalometric craniofacial features of patients with Sagliker syndrome: a primary analysis of our experience
Jiao-Ping Mi, Peng He, Kai Shi, Shao-Yan Feng, Xian-Zhen Chen, Qing-Qing He, Ming-Yue Zhao, Ping-Jiang Ge, Yun-Ping Fan
Annals of Translational Medicine  
2021;
9
(12)
:963
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 (29 June 2021) 
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Development of a new EGFR antibody antagonist which exhibits potential biological effects against laryngeal cancer
Kai Ren, Binquan Wang, Qingyan Qi
Annals of Translational Medicine  
2021;
9
(12)
:964
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 (29 June 2021) 
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Vof16-miR-205-Gnb3 axis regulates hippocampal neuron functions in cognitively impaired diabetic rats
Wenfang Peng, Bojin Xu, Xiaoxu Ge, Juan Du, Liuqing Xi, Lili Xia, Qianqian Wang, Shan Huang
Annals of Translational Medicine  
2021;
9
(12)
:965
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 (29 June 2021) 
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Risk scoring system for recurrence after simultaneous resection of colorectal cancer liver metastasis
Yuchen Wu, Tianan Guo, Zhenhong Xu, Fangqi Liu, Sanjun Cai, Lu Wang, Ye Xu
Annals of Translational Medicine  
2021;
9
(12)
:966
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 (29 June 2021) 
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Genetic differences between lung metastases and liver metastases from left-sided microsatellite stable colorectal cancer: next generation sequencing and clinical implications
Zhenghang Wang, Xue Zheng, Xicheng Wang, Yawei Chen, Zhongwu Li, Jianing Yu, Wanning Yang, Beibei Mao, Henghui Zhang, Jian Li, Lin Shen
Annals of Translational Medicine  
2021;
9
(12)
:967
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 (29 June 2021) 
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Feasibility of anterior pedicle screw fixation in lumbosacral spine: a radiographic and cadaveric study
Wei-Xing Xu, Bin Xu, Wei-Guo Ding, Hong-Feng Sheng, Di Lu, Tian-Hong Hu
Annals of Translational Medicine  
2021;
9
(12)
:968
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 (29 June 2021) 
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The use of explainable artificial intelligence to explore types of fenestral otosclerosis misdiagnosed when using temporal bone high-resolution computed tomography
Weimin Tan, Pengfei Guan, Lingjie Wu, Hedan Chen, Jichun Li, Yu Ling, Ting Fan, Yunfeng Wang, Jian Li, Bo Yan
Annals of Translational Medicine  
2021;
9
(12)
:969
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 (29 June 2021) 
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SV-VATS exhibits dual intraoperative and postoperative advantages
Jia-Yang Xu, Yu-Jin Li, Xian-Gu Ning, Yang Yu, Feng-Xian Cui, Rong-Sheng Liu, Hao Peng, Zhan-Shan Ma, Jun Peng
Annals of Translational Medicine  
2021;
9
(12)
:970
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 (29 June 2021) 
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Norcantharidin triggers apoptotic cell death in non-small cell lung cancer via a mitophagy-mediated autophagy pathway
Zhilong Liu, Baoxia Li, Mingrong Cao, Jianwei Jiang
Annals of Translational Medicine  
2021;
9
(12)
:971
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 (29 June 2021) 
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The role of ultrasound in determining the amount of pleural effusion
Xiao-Ning Liang, Chao-Yang Lv, Huan-Zhong Shi, Rui-Jun Guo, Shuo Li
Annals of Translational Medicine  
2021;
9
(12)
:972
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 (29 June 2021) 
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Pathological features of persistent adnexal masses in pregnancy
Zhiqiang Zhang, Xiaojuan Zheng, Miao Zhang, Jinfeng Li, Jing Zhao, Jing Zheng, Shuzhen Wang
Annals of Translational Medicine  
2021;
9
(12)
:973
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 (29 June 2021) 
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Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats
Peng Qiu, Yang Liu, Keyan Chen, Youjing Dong, Shiqing Liu, Jin Zhang
Annals of Translational Medicine  
2021;
9
(12)
:974
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 (29 June 2021) 
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Identification of genes predicting unfavorable prognosis in hepatitis B virus-associated hepatocellular carcinoma
Meng Sha, Jie Cao, Zhi-Peng Zong, Ning Xu, Jian-Jun Zhang, Ying Tong, Qiang Xia
Annals of Translational Medicine  
2021;
9
(12)
:975
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 (29 June 2021) 
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Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery
Baoqian Zhai, Jia Chen, Jiacheng Wu, Lei Yang, Xiaoli Guo, Jingjing Shao, Hong Xu, Aiguo Shen
Annals of Translational Medicine  
2021;
9
(12)
:976
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 (29 June 2021) 
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Thoracic full-endoscopic unilateral laminotomy with bilateral decompression for treating ossification of the ligamentum flavum with myelopathy
Yong-Peng Lin, Rui Lin, Song Chen, Si-Yuan Rao, Shuai Zhao, Tao Wen, Hong-Shen Wang, Wei-Xiong Hu, Bing-Xin Liu, Xin-Yi Li, Yong-Jin Li, Bo-Lai Chen
Annals of Translational Medicine  
2021;
9
(12)
:977
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 (29 June 2021) 
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Autophagy attenuates particulate matter 2.5-induced damage in HaCaT cells
Yu Dai, Yinghui Wang, Sheng Lu, Xuyi Deng, Xinli Niu, Zhi Guo, Rui Qian, Meijuan Zhou, Xuebiao Peng
Annals of Translational Medicine  
2021;
9
(12)
:978
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 (29 June 2021) 
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Caloric restriction inhibits renal artery ageing by reducing endothelin-1 expression
Xiao-Hua Wang, Qiang-Guo Ao, Qing-Li Cheng
Annals of Translational Medicine  
2021;
9
(12)
:979
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 (29 June 2021) 
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Defecation delay in patients after lung tumor surgery: a prospective nested case-control study
Jinbo Li, Tianzhen Yang, Lijuan Cen, Yaqing Liang, Chao Jiang, Junying Chen, Xiaomeng Dou, Wuling Mo, Li Liu, Yufan Chen
Annals of Translational Medicine  
2021;
9
(12)
:980
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 (29 June 2021) 
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A novel peptide promotes human trophoblast proliferation and migration through PI3K/Akt/mTOR signaling pathway
Li Ling, Xiao Yuan, Xia Liu, Wenjun Pei, Ranran Li
Annals of Translational Medicine  
2021;
9
(12)
:981
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 (29 June 2021) 
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Lin28A promotes the proliferation and stemness of lung cancer cells via the activation of mitogen-activated protein kinase pathway dependent on microRNA let-7c
Rui Zhang, Pengpeng Liu, Xiao Zhang, Yingnan Ye, Jinpu Yu
Annals of Translational Medicine  
2021;
9
(12)
:982
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 (29 June 2021) 
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Retrospective comparison of high-resolution computed tomography of eosinophilic granulomatosis with polyangiitis with severe asthma
Xiaofeng Lin, Yuejiao Lin, Zhengdao Lai, Shushan Wei, Minzhi Qiu, Jianyu Li, Qin Liu, Kian Fan Chung, Qingsi Zeng, Qingling Zhang
Annals of Translational Medicine  
2021;
9
(12)
:983
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 (29 June 2021) 
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In vitro and in vivo study on prevention of myocardial ischemic injury by taurine
Fengyun Ren, Xing Liu, Xiaoxue Liu, Yanli Cao, Lantao Liu, Xingjiang Li, Yingjun Wu, Shudi Du, Guozhong Tian, Jing Hu
Annals of Translational Medicine  
2021;
9
(12)
:984
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 (29 June 2021) 
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Integration of clinicopathological and mutational data offers insight into lung cancer with tumor spread through air spaces
Yu Tian, Jing Feng, Long Jiang, Junwei Ning, Zenan Gu, Jia Huang, Qingquan Luo
Annals of Translational Medicine  
2021;
9
(12)
:985
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 (29 June 2021) 
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High expression of PYCARD is an independent predictor of unfavorable prognosis and chemotherapy resistance in glioma
Aijun Liang, Shupeng Zhong, Bin Xi, Chaoyang Zhou, Xingxing Jiang, Ronglan Zhu, Yu Yang, Liangchen Zhong, Dengfeng Wan
Annals of Translational Medicine  
2021;
9
(12)
:986
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 (29 June 2021) 
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Long-term outcomes of a totally thoracoscopic approach for reoperative mitral valve replacement: a propensity score matched analysis
Peijian Wei, Jian Liu, Jiexu Ma, Yuyuan Zhang, Zhao Chen, Yanjun Liu, Tong Tan, Hongxiang Wu, Jimei Chen, Jian Zhuang, Huiming Guo
Annals of Translational Medicine  
2021;
9
(12)
:987
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 (29 June 2021) 
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Clinical course and outcomes of COVID-19 patients with a history of cerebrovascular disease: a retrospective study in Wuhan
Yang Bai, Yong Liang, Fang Wang, Ligang Chen, Yulong Zhao, Shoujie Zhao, Yejing Zhu, Yushu Dong, Guobiao Liang, Dongfeng Chen, Lei Liu
Annals of Translational Medicine  
2021;
9
(12)
:988
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 (29 June 2021) 
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Factors associated with corneal high-order aberrations before and after femtosecond laser-assisted in situ keratomileusis
Jun Zeng, Gongpu Lan, Min Zhu, Kai Sun, Qun Shi, Guoqing Ma, Quan Liu
Annals of Translational Medicine  
2021;
9
(12)
:989
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 (29 June 2021) 
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Development of a prediction model for the risk of recurrent laryngeal nerve lymph node metastasis in thoracolaparoscopic esophagectomy with cervical anastomosis
Guoqing Zhang, Yuanqi Li, Qian Wang, Huiwen Zheng, Lulu Yuan, Zhen Gao, Jindong Li, Xiangnan Li, Song Zhao
Annals of Translational Medicine  
2021;
9
(12)
:990
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 (29 June 2021) 
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Upregulation of PAIP1 promotes the gallbladder tumorigenesis through regulating PLK1 level
Jianping Bi, Hong Ma, Yafei Liu, Ai Huang, Yong Xiao, Wen-Jie Shu, Haining Du, Tao Zhang
Annals of Translational Medicine  
2021;
9
(12)
:991
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 (29 June 2021) 
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SIX1/EYA1 are novel liver damage biomarkers in chronic hepatitis B and other liver diseases
Baoyan Xu, Qiao Yang, Yingzi Tang, Zhaoxia Tan, Haiyan Fu, Jing Peng, Xiaomei Xiang, Linlin Gan, Guohong Deng, Qing Mao, Pin-Xian Xu, Yi Jiang, Jianqiang Ding
Annals of Translational Medicine  
2021;
9
(12)
:992
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 (29 June 2021) 
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Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration
Juan Zhou, Weiguo Li, Xiang Wen, Dan Zeng, Jilei Lin, Shiyi Chen, Na Zang, Yu Deng, Xiaohong Xie, Luo Ren, Enmei Liu
Annals of Translational Medicine  
2021;
9
(12)
:993
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 (29 June 2021) 
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A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer’s disease model
Lusheng Wang, Rongrong Jing, Xing Wang, Baohui Wang, Keke Guo, Jungang Zhao, Shuang Gao, Nuo Xu, Xuan Xuan
Annals of Translational Medicine  
2021;
9
(12)
:994
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 (29 June 2021) 
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The effect of docosahexaenoic acid on predicting the survival of patients with idiopathic pulmonary arterial hypertension
Xu Huai, Yuanyuan Sun, Xiuying Sun, Wenhui Wu, Lan Wang, Rong Jiang, Sugang Gong, Jinling Li, Yuqing Miao, Ping Yuan, Qinhua Zhao
Annals of Translational Medicine  
2021;
9
(12)
:995
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 (29 June 2021) 
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Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis
Bo Cao, Zhaoxia Xu, Chang Liu, Jian Hu, Zhongli Zhu, Junya Li, Guoyun Zhu, Fuxiang Li
Annals of Translational Medicine  
2021;
9
(12)
:996
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 (29 June 2021) 
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MCTS1 promotes invasion and metastasis of oral cancer by modifying the EMT process
Zhexun Huang, Qiao Su, Wuguo Li, Hui Ren, Huiqiang Huang, Anxun Wang
Annals of Translational Medicine  
2021;
9
(12)
:997
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 (29 June 2021) 
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The impact of adjuvant therapy on survival for node-negative esophageal squamous cell carcinoma: a propensity score-matched analysis
Xuyang Deng, Wenwu He, Yingchun Jiang, Sijie Deng, Tianqin Mao, Xuefeng Leng, Qiyu Luo, Kai Zheng, Yongtao Han
Annals of Translational Medicine  
2021;
9
(12)
:998
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 (29 June 2021) 
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The central nervous system can directly regulate breast cancer progression and blockage by quercetin
Tianyu Luo, Yanmei Zhang, Xiaoyuan Liu, Qianyi Liang, Ling Zhu, Hai Lu, Huachao Li, Hongyan Zhang, Chunmin Yang, Jiahua Wu, Rui Xu, Yuzhu Zhang, Qianjun Chen
Annals of Translational Medicine  
2021;
9
(12)
:999
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 (29 June 2021) 
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A randomized trial of use of a modified reverse sural neurofasciocutaneous flap to extend the reconstruction range
Xin Huang, Jihua Xu, Hu Yang, Haifei Shi
Annals of Translational Medicine  
2021;
9
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:1000
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 (29 June 2021) 
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Apatinib enhances the anti-tumor effect of paclitaxel via the PI3K/p65/Bcl-xl pathway in triple-negative breast cancer
Jing Chen, Shuzhen Deng, Yifan Zhang, Chaokun Wang, Xiaochen Hu, Dejiu Kong, Gaofeng Liang, Xiang Yuan, Yuanpei Li, Xinshuai Wang
Annals of Translational Medicine  
2021;
9
(12)
:1001
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 (29 June 2021) 
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Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist
Yongjie Yang, Yanfang Ma, Jingli Lu, Shuzhang Du, Jingmin Zhang, Haiyang Meng, Zhe Chen, Qiwen Zhang, Xiaojian Zhang, Wenyin Shi, Francesco Girolamo, Santiago Cepeda, Jian Kang
Annals of Translational Medicine  
2021;
9
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:1002
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 (29 June 2021) 
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Evaluation of the reporting quality of guidelines for gastric cancer using the RIGHT checklist
Xuan Wu, Ding Li, Haiyang Chen, Jing Han, Hanqiong Zhou, Zhen He, Yanfang Ma, Bingqi Dong, Yingxi Wu, Kristina A. Matkowskyj, Aslam Ejaz, Khaldoun Almhanna, Qiming Wang
Annals of Translational Medicine  
2021;
9
(12)
:1003
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 (29 June 2021) 
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An evaluation of the reporting quality in clinical practice guidelines for hepatocellular carcinoma using the RIGHT checklist
Haiyang Chen, Meng Tao, Ding Li, Jing Han, Cheng Cheng, Yanfang Ma, Yingxi Wu, Vishal G. Shelat, Francisco Tustumi, Sanjaya K. Satapathy, Koo Jeong Kang, Qiming Wang
Annals of Translational Medicine  
2021;
9
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:1004
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 (29 June 2021) 
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LncRNA-TCONS_00034812 is upregulated in atherosclerosis and upregulates miR-21 through methylation in vascular smooth muscle cells
Dongsheng Lin, Xian Zhang, Chiyuan Zhang, Qiao Jin, Luping Jiang
Annals of Translational Medicine  
2021;
9
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:1005
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 (29 June 2021) 
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A modified endocardial radiofrequency ablation approach for hypertrophic obstructive cardiomyopathy guided by transthoracic echocardiography: a case series
Lingqiu Kong, Yongchao Zhao, Hongwei Pan, Jianying Ma, Juying Qian, Junbo Ge
Annals of Translational Medicine  
2021;
9
(12)
:1006
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 (29 June 2021) 
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Screening and prognostic value of potential biomarkers for ovarian cancer
Huiqin Li, Ming Li, Chunhui Tang, Liang Xu
Annals of Translational Medicine  
2021;
9
(12)
:1007
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 (29 June 2021) 
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Tumor protein D52 promotes breast cancer proliferation and migration via the long non-coding RNA NEAT1/microRNA-218-5p axis
Jing Ren, Yunzi Chen, Weishu Kong, Ye Li, Feng Lu
Annals of Translational Medicine  
2021;
9
(12)
:1008
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 (29 June 2021) 
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18F-fluorodeoxyglucose positron emission tomography—based prediction for splenectomy in patients with suspected splenic lymphoma
Yingwei Hu, Weiyan Zhou, Siyuan Sun, Yihui Guan, Jiexian Ma, Yanhui Xie
Annals of Translational Medicine  
2021;
9
(12)
:1009
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 (29 June 2021) 
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Collagen sponge prolongs taurine release for improved wound healing through inflammation inhibition and proliferation stimulation
Liang Wu, Qianwen Zhang, Yuan Li, Wenxiang Song, Anqi Chen, Jingjing Liu, Xuan Xuan
Annals of Translational Medicine  
2021;
9
(12)
:1010
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 (29 June 2021) 
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RAB5C, SYNJ1, and RNF19B promote male ankylosing spondylitis by regulating immune cell infiltration
Di Zhang, Bo Li, Rui Guo, Jionglin Wu, Canchun Yang, Xu Jiang, Chi Zhang, Haolin Yan, Qiancheng Zhao, Zheyu Wang, Qiwei Wang, Renyuan Huang, Zhilei Zhang, Xumin Hu, Liangbin Gao
Annals of Translational Medicine  
2021;
9
(12)
:1011
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 (29 June 2021) 
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Study on the interaction mechanism between C-reactive protein and platelets in the development of acute myocardial infarction
Yubao Liu, Shuhui Lai, Lijie Liang, Donghai Zhang
Annals of Translational Medicine  
2021;
9
(12)
:1012
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 (29 June 2021) 
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Single-docking robotic assisted proctectomy for rectal cancer below peritoneal reflection: a propensity score matching analysis
Tao Zhang, Zijia Song, Yaqi Zhang, Feng Ye, Xi Cheng, Shaodong Wang, Xiaoqian Jing, Xiaopin Ji, Ren Zhao
Annals of Translational Medicine  
2021;
9
(12)
:1013
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 (29 June 2021) 
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Outcomes of switching from crizotinib to alectinib in patients with advanced non-small cell lung cancer with anaplastic lymphoma kinase fusion
Yingying Pan, Wenjing Xiao, Feng Ye, Huijuan Wang, Yihong Shen, Xinmin Yu, Xiao Han, Qian Chu, Caicun Zhou, Zhihong Zhang, Shengxiang Ren
Annals of Translational Medicine  
2021;
9
(12)
:1014
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 (29 June 2021) 
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Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice
Chaochao Wei, Linhui Huang, Yamei Zheng, Xingjun Cai
Annals of Translational Medicine  
2021;
9
(12)
:1015
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 (29 June 2021) 
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Beta-1 syntrophin (SNTB1) regulates colorectal cancer progression and stemness via regulation of the Wnt/β-catenin signaling pathway
Yanfang Liang, Bin Wang, Shasha Chen, Ziyu Ye, Xingxing Chai, Ronggang Li, Xiaoping Li, Gang Kong, Yanyun Li, Xueying Zhang, Zhengping Che, Qi Xie, Jiachun Lian, Bihua Lin, Xin Zhang, Xueqin Huang, Weijuan Huang, Xianxiu Qiu, Jincheng Zeng
Annals of Translational Medicine  
2021;
9
(12)
:1016
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 (29 June 2021) 
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Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals distinct cancer-associated fibroblasts in head and neck squamous cell carcinoma
Qian Zhang, Yuxin Wang, Chengwan Xia, Liang Ding, Yumei Pu, Xiaobei Hu, Huiming Cai, Qingang Hu
Annals of Translational Medicine  
2021;
9
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:1017
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 (29 June 2021) 
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Up-regulated long noncoding RNA AC007128.1 and its genetic polymorphisms associated with Tuberculosis susceptibility
Hong Yan, Guoye Liu, Yuan Liang, Wei Wu, Rui Xia, Lin Jiao, Han Shen, Zhijun Jia, Qian Wang, Zhiqiang Wang, Yi Kong, Binwu Ying, Hualiang Wang, Chengbin Wang
Annals of Translational Medicine  
2021;
9
(12)
:1018
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 (29 June 2021) 
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The prognostic value of USP14 and PSMD14 expression in non-small cell lung cancer
Jian Lei, Xiaoliu Liu, Wei Liu, Yun Zhang, Zhihong Liu
Annals of Translational Medicine  
2021;
9
(12)
:1019
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 (29 June 2021) 
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The role of informal caregivers for patients with glioma: a systematic review and meta-synthesis of qualitative studies
Dan Chen, Jinfeng Zhu, Qiuning Xu, Fang Wang, Cuiling Ji, Hengdan Di, Ping Yuan, Xiaoyan Bai, Lu Chen
Annals of Translational Medicine  
2021;
9
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:1020
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 (29 June 2021) 
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Prostaglandin F2α protects against pericyte apoptosis by inhibiting the PI3K/Akt/GSK3β/β-catenin signaling pathway
Ying Cheng, Liyuan Peng, Xiaoqing Deng, Ting Li, Hang Guo, Chaofei Xu, Ting Fang, Xiaohuan Liu, Bei Sun, Liming Chen
Annals of Translational Medicine  
2021;
9
(12)
:1021
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 (29 June 2021) 
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Establishment of a prognostic-related microRNAs risk model for glioma by bioinformatics analysis
Yunkun Wang, Chenran Zhang, Weiwei Lu, Ruoping Chen, Mingkun Yu
Annals of Translational Medicine  
2021;
9
(12)
:1022
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 (29 June 2021) 
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LncRNA TCONS_00004099-derived microRNA regulates oncogenesis through PTPRF in gliomas
Yuhao Wang, Aijun Shan, Zhiwei Zhou, Wenpeng Li, Lin Xie, Bo Du, Bingxi Lei
Annals of Translational Medicine  
2021;
9
(12)
:1023
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 (29 June 2021) 
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A randomized trial comparing the clinical efficacy and safety of a novel steerable percutaneous kyphoplasty with traditional PKP in osteoporotic vertebral fractures
Jizheng Li, Xiaofeng Yuan, Fanbing Li, Yi Ding, Gang Ma, Chao Song, Xuesong Chen, Enbin Wang, Jiaping Cui, Qingli Kong, Youqing Huang, En Song
Annals of Translational Medicine  
2021;
9
(12)
:1024
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 (29 June 2021) 
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Clinical effectiveness of orthodontic miniscrew implantation guided by a novel cone beam CT image-based computer aided design and computer aided manufacturing (CAD-CAM) template
Lingling Qiu, Hui Xu, Pingping Feng, Xiaoyan Sha, Hongwei Zhang
Annals of Translational Medicine  
2021;
9
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:1025
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 (29 June 2021) 
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Review Article

Surgical treatment of locally recurrent rectal cancer: a narrative review
Zhaoya Gao, Jin Gu
Annals of Translational Medicine  
2021;
9
(12)
:1026
.
 (29 June 2021) 
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Case Report

Intensive multidisciplinary treatment strategies and patient resilience to challenge long-term survival in metastatic colorectal cancer: a case report in real life and clinical practice
Gemma Bruera, Francesco Pepe, Umberto Malapelle, Mario Di Staso, Antonella Dal Mas, Daniela Di Giacomo, Gaia Scerbo, Michela Santilli, Eugenio Ciacco, Maurizio Simmaco, Giancarlo Troncone, Claudio Coco, Felice Giuliante, Enrico Ricevuto; on behalf of Oncology Network ASL1 Abruzzo
Annals of Translational Medicine  
2021;
9
(12)
:1027
.
 (29 June 2021) 
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A rare survival case of blunt left ventricular rupture caused by a low-energy pedestrian collision with a stationary forklift: a case report
Huangkai Zhu, Chenxu Zhang, Weidi Zhao, Xiang Xu, Yiting Shi, Guofang Zhao
Annals of Translational Medicine  
2021;
9
(12)
:1028
.
 (29 June 2021) 
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Letter to the Editor

Response to: effect of vasa vasorum in cerebrovascular compensation: 2 case reports
Long Li, Adam A. Dmytriw, Liqun Jiao
Annals of Translational Medicine  
2021;
9
(12)
:1029
.
 (29 June 2021) 
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Elevated lipoprotein(a) and risk of coronary heart disease according to different lipid profiles in the general Chinese community population: the CHCN-BTH study
Yong Hu, Yong-Ming He
Annals of Translational Medicine  
2021;
9
(12)
:1030
.
 (29 June 2021) 
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New insights into mechanisms of Alzheimer’s disease revealed by a dynamic functional magnetic resonance imaging study
Yicheng Long
Annals of Translational Medicine  
2021;
9
(12)
:1031
.
 (29 June 2021) 
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Editorial on Cancer Immunotherapy: Recent Advances and Challenges1

Cancer immunotherapy: recent advances and challenges
Umang Swami, Mohammed Milhem
Annals of Translational Medicine  
2021;
9
(12)
:1032
.
 (29 June 2021) 
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Original Article on Cancer Immunotherapy: Recent Advances and Challenges1

Safety of immune checkpoint inhibitors in patients with cancer and pre-existing autoimmune disease
Swetha Alexander, Umang Swami, Aneet Kaur, Yubo Gao, Munazza Fatima, Meredith M. Ginn, Jill E. Stein, Petros Grivas, Yousef Zakharia, Namrata Singh
Annals of Translational Medicine  
2021;
9
(12)
:1033
.
 (29 June 2021) 
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Review Article on Cancer Immunotherapy: Recent Advances and Challenges1

The role of gut microbiome in modulating response to immune checkpoint inhibitor therapy in cancer
Abdul Rafeh Naqash, Alba J. Kihn-Alarcón, Chara Stavraka, Kathleen Kerrigan, Saman Maleki Vareki, David James Pinato, Sonam Puri
Annals of Translational Medicine  
2021;
9
(12)
:1034
.
 (29 June 2021) 
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Considerations for immunotherapy in patients with cancer and comorbid immune dysfunction
Vaia Florou, Sonam Puri, Ignacio Garrido-Laguna, Breelyn A. Wilky
Annals of Translational Medicine  
2021;
9
(12)
:1035
.
 (29 June 2021) 
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CAR T-cell therapy in mature lymphoid malignancies: clinical opportunities and challenges
Mayur Narkhede, Amitkumar Mehta, Stephen M. Ansell, Gaurav Goyal
Annals of Translational Medicine  
2021;
9
(12)
:1036
.
 (29 June 2021) 
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Immune checkpoint inhibitors in lymphoma: challenges and opportunities
Haris Hatic, Devi Sampat, Gaurav Goyal
Annals of Translational Medicine  
2021;
9
(12)
:1037
.
 (29 June 2021) 
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Current status of intralesional agents in treatment of malignant melanoma
Misam Zawit, Umang Swami, Hassan Awada, Joyce Arnouk, Mohammed Milhem, Yousef Zakharia
Annals of Translational Medicine  
2021;
9
(12)
:1038
.
 (29 June 2021) 
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Turning ‘Cold’ tumors ‘Hot’: immunotherapies in sarcoma
Jeff Rytlewski, Mohammed M. Milhem, Varun Monga
Annals of Translational Medicine  
2021;
9
(12)
:1039
.
 (29 June 2021) 
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Biomarkers of therapeutic response with immune checkpoint inhibitors
Poorva Bindal, Jhanelle E. Gray, Theresa A. Boyle, Vaia Florou, Sonam Puri
Annals of Translational Medicine  
2021;
9
(12)
:1040
.
 (29 June 2021) 
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The dark side of immunotherapy
Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami
Annals of Translational Medicine  
2021;
9
(12)
:1041
.
 (29 June 2021) 
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Disclosure:

1. The series “Cancer Immunotherapy: Recent Advances and Challenges” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Umang Swami and Mohammed Milhem served as the unpaid Guest Editors for the series.