Importance of tumor infiltrating lymphocytes in non-small cell lung cancer?

Lung cancer, of which non-small cell lung cancer (NSCLC; 85%) is the largest subgroup, constitute our most deadly malignant disease with a 5-year survival of merely 15% (1). This malignancy, as well as other solid neoplasms, is not simply an accumulation of malignant cells, but represents also a microenvironment containing endothelial cells, fibroblasts, structural components and infiltrating immune cells. This microenvironment highly influences tumor development, invasion, metastasis and patient outcome.