Vol 14, No 4 (August 31, 2026): Annals of Translational Medicine

Original Article | Clinical Studies

Association between rheumatoid arthritis, frailty status, mortality and anti-cancer therapy: a retrospective SEER-Medicare analysis in patients with non-metastatic renal cell carcinoma
Sherwin Novin, Sarah K. Holt, Maya Swaminathan, Jonathan Wright, John Gore, Kimme Hyrich, Sizheng Steven Zhao, Jeffrey Sparks, Una Makris, Maria Suarez-Almazor, Petros Grivas, Sarah Psutka, Namrata Singh
Annals of Translational Medicine  
2026;
14
(4)
:47
.
The potential of large language models to address patients’ preoperative questions before anterior cervical discectomy and fusion surgery
Erika Yamazawa, Ziad Rifi, John K. Houten, James D. Lin, Konstantinos Margetis, Jeremy Steinberger
Annals of Translational Medicine  
2026;
14
(4)
:48
.

Original Article | Drug and Biomaterials Screening and Development

A comprehensive longitudinal study quantifying the systemic effects associated with ovariectomy and high-dose corticosteroids in a sheep model of osteoporosis
Katie T. Bisazza, Brad B. Nelson, Russell V. Anthony, Laurie R. Goodrich, Kirk C. McGilvray, Jeremiah T. Easley
Annals of Translational Medicine  
2026;
14
(4)
:49
.

Review Article | Biomarkers Sciences

Individualized pharmacotherapy: background and development
Jan Trøst Jørgensen, Niels Westergaard
Annals of Translational Medicine  
2026;
14
(4)
:50
.
Ferritin as a diagnostic point-of-care marker in iron deficiency anemia: a narrative review and clinical implications
Janeva Nicole Dimen, Mohammad Sunoqrot, Catherine Hobbs, Emma Cherayil, Daven Sharma, Homa K. Ahmadzia
Annals of Translational Medicine  
2026;
14
(4)
:51
.
Tumor microenvironment and signaling pathways in melanoma brain metastasis
Rafael Rosell, María González-Cao, Daniel Olmo-González, Emilia Hold, Miguel Ángel Molina-Vila
Annals of Translational Medicine  
2026;
14
(4)
:52
.

Review Article | Data-Driven Clinical Practice and Policy Making

Literature review of pediatric Erdheim-Chester disease (ECD) and mixed histiocytosis (Langerhans cell histiocytosis/ECD)
Shinsaku Imashuku
Annals of Translational Medicine  
2026;
14
(4)
:53
.

Review Article | Basic and Mechanism Sciences

A developmentally informed narrative review of Toll-like receptors in adult and pediatric acute respiratory distress syndrome
Clare Wei Tian Foo, Herng Lee Tan, Jing Yao Leong, Joo Guan Yeo, Salvatore Albani, Judith Ju Ming Wong
Annals of Translational Medicine  
2026;
14
(4)
:54
.

Editorial Commentary | Emerging Therapeutics

Could chimeric antigen receptor-T cell treatment of atherosclerosis in mice translate to a human therapy?
Steven Gieseg, Barry Hock, Martins Ogugofor, Sally McCormick
Annals of Translational Medicine  
2026;
14
(4)
:55
.

Editorial Commentary | Emerging Medical Technology Innovation and Translation

Direct selective laser trabeculoplasty in glaucoma: insights from the GLAUrious study
Daniel Zhu, Charles Zhang, Paras Shah, Amanda Bicket
Annals of Translational Medicine  
2026;
14
(4)
:56
.

Editorial Commentary | Clinical Studies

Beyond the numbers: hypotension, algorithms, and the elusive promise of renal protection
Rogerio da Hora Passos, Rafael Hortêncio Melo, Roberto Rabello Filho, Bruno Zawadzki, Olfa Hamzaoui
Annals of Translational Medicine  
2026;
14
(4)
:57
.
Comments on Diversified segmental defocus optimization lenses with and without atropine for myopia prevention: a randomized clinical trial
Langis Michaud
Annals of Translational Medicine  
2026;
14
(4)
:58
.
Screening for atrial fibrillation according to serum thyroid-stimulating hormone: an opportunity for refinement?
Akash Kamalakshan Mavilakandy, Gregory Y. H. Lip
Annals of Translational Medicine  
2026;
14
(4)
:59
.

Letter to the Editor | Drug and Biomaterials Screening and Development

Morphine versus hydromorphone pharmacokinetic vs. pharmacodynamic variabilities
Konrad Meissner, Erik Olofsen, Albert Dahan, Evan D. Kharasch
Annals of Translational Medicine  
2026;
14
(4)
:60
.