This series aims to provide some insight and overviews on the challenges in conducting clinical trials, including Eastern and Western perspectives.
FOLFOXIRI plus bevacizumab in the treatment of metastatic colorectal cancer patients with unresectable liver metastases
Novel clinical trial design and analytic methods to tackle challenges in therapeutic development in rare diseases
Current usage and challenges of master protocols—based on survey results by ASA BIOP oncology methodology working group master protocol sub-team
mFOLFOXIRI with or without bevacizumab for conversion therapy of RAS/BRAF/PIK3CA mutant unresectable colorectal liver metastases: the FORBES non-randomized phase II trial
The prognostic and predictive value of mismatch repair status in patients with locally advanced rectal cancer following neoadjuvant therapy
Development and validation of the interpretability analysis system based on deep learning model for smart image follow-up of nail pigmentation
Structured training curriculums for transanal total mesorectal excision in China: refinement is needed
Systemic glucocorticoid-free therapy with adalimumab plus immunosuppressants versus conventional therapy in treatment-naïve Vogt-Koyanagi-Harada disease patients
Clinical study of poorly differentiated head and neck squamous cell carcinoma: a prospective cohort study in China
The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial
Development and external validation of prognostic nomograms for liver disease-free and overall survival in locally advanced rectal cancer with neoadjuvant therapy: a post cohort study based on the FOWARC trial
The predictive value of tumor volume reduction ratio on three-dimensional endorectal ultrasound for tumor response to chemoradiotherapy for locally advanced rectal cancer
Prognostic impact of high-risk factors and KRAS mutation in patients with stage II deficient mismatch repair colon cancer: a retrospective cohort study
The series “Challenges in Clinical Trials” was commissioned by the editorial office, Annals of Translational Medicine without any sponsorship or funding. Dr. Weiping Wen, Dr. Yanhong Deng, Dr. Qian Shi and Dr. Jun (Vivien) Yin are serving as the unpaid Guest Editors for the series.