Most Read article list (ranking real-time pageviews since the publication of the article)

Ali Hasan Ebrahim, Zainab Alalawi, Leonardo Mirandola, Rahman Rakhshanda, Scott Dahlbeck, Diane Nguyen, Marjorie Jenkins, Fabio Grizzi, Everardo Cobos, Jose A. Figueroa, Maurizio Chiriva-Internati

Published online: 20 September 2014

PDF Pages: 88 Full Text (11454) Open Access

Review Article

Inhalation therapies in acute respiratory distress syndrome

Antonio Artigas, Marta Camprubí-Rimblas, Neus Tantinyà, Josep Bringué, Raquel Guillamat-Prats, Michael A. Matthay

Published online: 25 July 2017

PDF Pages: 293 Full Text (11497) Open Access

Review Article

Companion diagnostics—a tool to improve pharmacotherapy

Jan Trøst Jørgensen, Maria Hersom

Published online: 29 December 2016

PDF Pages: 482 Full Text (11374) Open Access

Review Article on Translational Neurodegeneration

Tau in neurodegenerative disease

Yong-Lei Gao, Nan Wang, Fu-Rong Sun, Xi-Peng Cao, Wei Zhang, Jin-Tai Yu

Published online: 26 May 2018

PDF Pages: 175 Full Text (11398) Open Access

Review Article on Primary Total Knee Arthroplasty

Rotational alignment of the femoral component in total knee arthroplasty

Claudio Carlo Castelli, Daniele Antonio Falvo, Mario Luigi Iapicca, Valerio Gotti

Published online: 11 January 2016

PDF Pages: 4 Full Text (11337) Open Access

Review Article

External beam techniques to boost cervical cancer when brachytherapy is not an option—theories and applications

Omar Mahmoud, Sarah Kilic, Atif J. Khan, Sushil Beriwal, William Small Jr

Published online: 24 May 2017

PDF Pages: 207 Full Text (11230) Open Access

Perspective

Gut microbiota and oxalate homeostasis

Marguerite Hatch

Published online: 19 January 2017

PDF Pages: 36 Full Text (11226) Open Access

Review Article

The importance of sagittal balance in adult scoliosis surgery

Jason Pui Yin Cheung

Published online: 15 January 2020

PDF Pages: 35 Full Text (11224) Open Access

Review Article

Electrical impedance tomography

Beatriz Lobo, Cecilia Hermosa, Ana Abella, Federico Gordo

Published online: 25 January 2018

PDF Pages: 26 Full Text (11134) Open Access

Review Article

Molecular subtypes and precision treatment of triple-negative breast cancer

Shen Zhao, Wen-Jia Zuo, Zhi-Ming Shao, Yi-Zhou Jiang

Published online: 16 April 2020

PDF Pages: 499 Full Text (11146) COI Form Open Access

Review Article

Molecular genetics of Pompe disease: a comprehensive overview

Paolo Peruzzo, Eleonora Pavan, Andrea Dardis

Published online: 15 July 2019

PDF Pages: 278 Full Text (11160) Open Access

Editorial

Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy

Qiongling Wang, Xander H. T. Wehrens

Published online: 31 October 2016

PDF Pages: S23 Full Text (11197) Open Access

Original Article

Metabolic biomarker signature for predicting the effect of neoadjuvant chemotherapy of breast cancer

Xiaojie Lin, Rui Xu, Siying Mao, Yuzhu Zhang, Yan Dai, Qianqian Guo, Xue Song, Qingling Zhang, Li Li, Qianjun Chen

Published online: 29 November 2019

PDF Pages: 670 Full Text (11139) Open Access

Review Article on Inborn Errors of Metabolism

Common metabolic disorder (inborn errors of metabolism) concerns in primary care practice

Marisha Agana, Julia Frueh, Manmohan Kamboj, Dilip R. Patel, Shibani Kanungo

Published online: 29 December 2018

PDF Pages: 469 Full Text (11172) Open Access

Review Article on Cardiopulmonary Interactions

Determinants of systemic venous return and the impact of positive pressure ventilation

David Berger, Jukka Takala

Published online: 27 September 2018

PDF Pages: 350 Full Text (11051) Open Access

Review Articles

One problem two issues! Left ventricular systolic and diastolic dysfunction in aortic stenosis

Maqsood M. Elahi, Anthony Chuang, Michael J. Ewing, Charles H. Choi, Peter W. Grant, Bashir M. Matata

Published online: 25 December 2013

PDF Pages: 10 Full Text (11024) Open Access

Original Article

Clinical significance and prognosis of supraclavicular lymph node metastasis in patients with thoracic esophageal cancer

Fudong Wang, Xiaosong Ge, Zhiqiang Wang, Yuan Weng, Rong Yin, Qingjun You

Published online: 29 February 2020

PDF Pages: 90 Full Text (11093) Open Access

Review Article on Carotid Artery Stenosis and Stroke: Prevention and Treatment Part I

Why are we still debating criteria for carotid artery stenosis?

Victor J. Del Brutto, Heather L. Gornik, Tatjana Rundek

Published online: 15 October 2020

PDF Pages: 1270 Full Text (11078) COI Form Open Access

Big-data Clinical Trial Column

Univariate description and bivariate statistical inference: the first step delving into data

Zhongheng Zhang

Published online: 11 March 2016

PDF Pages: 91 Full Text (10976) Open Access

Review Article on Myokines, Exercise and Cardiovascular Disease

Measuring myokines with cardiovascular functions: pre-analytical variables affecting the analytical output

Giovanni Lombardi, Veronica Sansoni, Giuseppe Banfi

Published online: 06 August 2017

PDF Pages: 299 Full Text (10827) Open Access

Review Article on Pain Therapy

Intranasal drugs for analgesia and sedation in children admitted to pediatric emergency department: a narrative review

Valeria Pansini, Antonietta Curatola, Antonio Gatto, Ilaria Lazzareschi, Antonio Ruggiero, Antonio Chiaretti

Published online: 30 January 2021

PDF Pages: 189 Full Text (10879) Reporting Checklist COI Form Open Access

Review Article

Adolescent idiopathic scoliosis: indications for bracing and conservative treatments

André J. Kaelin

Published online: 15 January 2020

PDF Pages: 28 Full Text (10857) Open Access

Review Article

Neoantigen-based cancer immunotherapy

Sara Bobisse, Periklis G. Foukas, George Coukos, Alexandre Harari

Published online: 28 July 2016

PDF Pages: 262 Full Text (10863) Open Access

Original Article

Thoracic sympathetic nerve reconstruction for compensatory hyperhidrosis: the Melbourne technique

Hye-Sung Park, Chris Hensman, James Leong

Published online: 29 May 2014

PDF Pages: 45 Full Text (10756) Open Access

Review Article on Biomarkers/Molecular Diagnostic Tools

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

Marios A. Diamantopoulos, Panagiotis Tsiakanikas, Andreas Scorilas

Published online: 30 June 2018

PDF Pages: 241 Full Text (10775) Open Access

Original Article

Preclinical safety evaluation of chimeric antigen receptor-modified T cells against CD19 in NSG mice

Hairuo Wen, Zhe Qu, Yujing Yan, Chengfei Pu, Chao Wang, Hua Jiang, Tiantian Hou, Yan Huo

Published online: 15 December 2019

PDF Pages: 735 Full Text (10731) Open Access

Review Articles

Functional role of microvesicles in gastrointestinal malignancies

Kelly McDaniel, Robert Correa, Tianhao Zhou, Christopher Johnson, Heather Francis, Shannon Glaser, Julie Venter, Gianfranco Alpini, Fanyin Meng

Published online: 06 March 2013

PDF Pages: 4 Full Text (10702) Open Access

Review Article

Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies

Evelyn M. Brosnan, Carey K. Anders

Published online: 15 May 2018

PDF Pages: 163 Full Text (10650) Open Access

Review Article on Cancer Immunotherapy: Recent Advances and Challenges

The dark side of immunotherapy

Nwanneka Okwundu, Douglas Grossman, Siwen Hu-Lieskovan, Kenneth F. Grossmann, Umang Swami

Published online: 29 June 2021

PDF Pages: 1041 Full Text (10632) COI Form Open Access

Review Article

Biology of MET: a double life between normal tissue repair and tumor progression

Iacopo Petrini

Published online: 21 April 2015

PDF Pages: 82 Full Text (10623) Open Access

Original Article

Factors that influence blood loss and need for transfusion following total knee arthroplasty

Achilleas Boutsiadis, Ryan Jacob Reynolds, Mo Saffarini, Jean-Claude Panisset

Published online: 02 November 2017

PDF Pages: 418 Full Text (10634) Open Access

Review Article

Application of next-generation sequencing technologies in Neurology

Teng Jiang, Meng-Shan Tan, Lan Tan, Jin-Tai Yu

Published online: 08 December 2014

PDF Pages: 125 Full Text (10692) Open Access

Perspective

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark, Komaraiah Palle

Published online: 29 December 2016

PDF Pages: 518 Full Text (10657) Open Access

Review Article

SOS response and its regulation on the fluoroquinolone resistance

Ting-Ting Qin, Hai-Quan Kang, Ping Ma, Peng-Peng Li, Lin-Yan Huang, Bing Gu

Published online: 23 December 2015

PDF Pages: 358 Full Text (10611) Open Access

Original Article

Platelet-rich plasma improves chronic inflammatory pain by inhibiting PKM2-mediated aerobic glycolysis in astrocytes

Xiang Wei, Xiao-Hong Jin, Xiao-Wen Meng, Jie Hua, Fu-Hai Ji, Li-Na Wang, Jian-Ping Yang

Published online: 15 November 2020

PDF Pages: 1456 Full Text (10597) Reporting Checklist Data Sharing Statement COI Form Open Access

Study Protocol

Effectiveness of enteral feeding protocol on clinical outcomes in critically ill patients: a study protocol for before-and-after design

Zhongheng Zhang, Qian Li, Lingzhi Jiang, Bo Xie, Xiaowei Ji, Jiahong Lu, Ronglin Jiang, Shu Lei, Shihao Mao, Lijun Ying, Di Lu, Xiaoshui Si, Jianxin He, Mingxia Ji, Jianhua Zhu, Guodong Chen, Yadi Shao, Yinghe Xu, Ronghai Lin, Chao Zhang, Weiwen Zhang, Jian Luo, Tianzheng Lou, Xuwei He, Kun Chen, Renhua Sun

Published online: 29 August 2016

PDF Pages: 308 Full Text (10596) Open Access

Review Article

Diagnosis and management of peripheral lung nodule

Taha Khan, Yasir Usman, Tony Abdo, Fawad Chaudry, Jean I. Keddissi, Houssein A. Youness

Published online: 14 August 2019

PDF Pages: 348 Full Text (10535) Open Access

Review Article

A narrative review of central nervous system involvement in acute leukemias

Dalma Deak, Nicolae Gorcea-Andronic, Valentina Sas, Patric Teodorescu, Catalin Constantinescu, Sabina Iluta, Sergiu Pasca, Ionut Hotea, Cristina Turcas, Vlad Moisoiu, Alina-Andreea Zimta, Simona Galdean, Jakob Steinheber, Ioana Rus, Sebastian Rauch, Cedric Richlitzki, Raluca Munteanu, Ancuta Jurj, Bobe Petrushev, Cristina Selicean, Mirela Marian, Olga Soritau, Alexandra Andries, Andrei Roman, Delia Dima, Alina Tanase, Olafur Sigurjonsson, Ciprian Tomuleasa

Published online: 15 January 2021

PDF Pages: 68 Full Text (10435) Reporting Checklist Peer Review File COI Form Open Access

Editorial

Real-time liquid biopsies become a reality in cancer treatment

Niki Karachaliou, Clara Mayo-de-las-Casas, Miguel Angel Molina-Vila, Rafael Rosell

Published online: 10 March 2015

PDF Pages: 36 Full Text (10500) Open Access

Review Article

Circulating biomarkers in epithelial ovarian cancer diagnosis: from present to future perspective

Martina Montagnana, Marco Benati, Elisa Danese

Published online: 14 July 2017

PDF Pages: 276 Full Text (10497) Open Access

Commentary

How to determine the treatment options for lower-pole renal stones

Bum Soo Kim

Published online: 29 August 2016

PDF Pages: 317 Full Text (10498) Open Access

Case Report

The worst of both worlds-combined pulmonary fibrosis and emphysema syndrome

Sheeba Habeeb Ba Aqeel, Abhishek Biswas, Peruvemba S. Sriram

Published online: 25 May 2016

PDF Pages: 196 Full Text (10492) Open Access

Review Article on MET as Actionable Target in Cancer Therapy

MET exon 14 juxtamembrane splicing mutations: clinical and therapeutical perspectives for cancer therapy

Sara Pilotto, Anastasios Gkountakos, Luisa Carbognin, Aldo Scarpa, Giampaolo Tortora, Emilio Bria

Published online: 13 January 2017

PDF Pages: 2 Full Text (10497) Open Access

Big-data Clinical Trial Column

Opening the black box of neural networks: methods for interpreting neural network models in clinical applications

Zhongheng Zhang, Marcus W. Beck, David A. Winkler, Bin Huang, Wilbert Sibanda, Hemant Goyal, written on behalf of AME Big-Data Clinical Trial Collaborative Group

Published online: 16 June 2018

PDF Pages: 216 Full Text (10484) Open Access

Review Article