Most Read article list (ranking real-time pageviews since the publication of the article)

Original Article

Coronavirus disease 2019 (COVID-19): chest CT characteristics benefit to early disease recognition and patient classification—a single center experience

Hua Zhou, Kaijin Xu, Yihong Shen, Qiang Fang, Feng Chen, Jifang Sheng, Feng Zhao, Haiyan Lou

Published online: 15 June 2020

PDF Pages: 679 Full Text (429623) Reporting Checklist Data Sharing Statement COI Form Open Access

Letter to the Editor

Serum lactate dehydrogenase level may predict acute respiratory distress syndrome of patients with fever infected by SARS-CoV-2

Yang Zhou, Ning Ding, Guifang Yang, Wen Peng, Fengning Tang, Cuirong Guo, Xiangping Chai

Published online: 15 September 2020

PDF Pages: 1118 Full Text (105651) COI Form Open Access

Review Article

Lung abscess-etiology, diagnostic and treatment options

Ivan Kuhajda, Konstantinos Zarogoulidis, Katerina Tsirgogianni, Drosos Tsavlis, Ioannis Kioumis, Christoforos Kosmidis, Kosmas Tsakiridis, Andrew Mpakas, Paul Zarogoulidis, Athanasios Zissimopoulos, Dimitris Baloukas, Danijela Kuhajda

Published online: 15 August 2015

PDF Pages: 183 Full Text (67529) Open Access

Review Article

Metformin use in women with polycystic ovary syndrome

Neil P. Johnson

Published online: 27 June 2014

PDF Pages: 56 Full Text (66524) Open Access

Review Article

Magnesium and liver disease

Meixi Liu, Huayu Yang, Yilei Mao

Published online: 31 October 2019

PDF Pages: 578 Full Text (55961) Open Access

Review Article

Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease

Wen-Ying Wang, Meng-Shan Tan, Jin-Tai Yu, Lan Tan

Published online: 26 June 2015

PDF Pages: 136 Full Text (54279) Open Access

Review Article

Metformin in cancer prevention and therapy

Jacek Kasznicki, Agnieszka Sliwinska, Józef Drzewoski

Published online: 27 June 2014

PDF Pages: 57 Full Text (51191) Open Access

Review Article

Epidemiology of coronary heart disease and acute coronary syndrome

Fabian Sanchis-Gomar, Carme Perez-Quilis, Roman Leischik, Alejandro Lucia

Published online: 15 July 2016

PDF Pages: 256 Full Text (49408) Open Access

Original Article

Molecular mechanism of CD163⁺ tumor-associated macrophage (TAM)-derived exosome-induced cisplatin resistance in ovarian cancer ascites

Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Jinhong Chen, Xiaoqing Guo

Published online: 29 September 2022

PDF Pages: 1014 Full Text (49087) Reporting Checklist Data Sharing Statement COI Form Open Access

Case Report

The potential detrimental effects of calcium channel blockers’ overdose and current available management

Manyoo A. Agarwal, David Flatt, Rami N. Khouzam

Published online: 15 January 2018

PDF Pages: 16 Full Text (48761) Open Access

Big-data Clinical Trial Column

Time-varying covariates and coefficients in Cox regression models

Zhongheng Zhang, Jaakko Reinikainen, Kazeem Adedayo Adeleke, Marcel E. Pieterse, Catharina G. M. Groothuis-Oudshoorn

Published online: 13 April 2018

PDF Pages: 121 Full Text (44925) Open Access

Original Article

Efficacy and safety of palbociclib plus endocrine therapy for patients with HR⁺/HER2⁻ advanced breast cancer in real-world clinical practice

Bingqian Zhong, Jie Zhang, Jing Wu, Langshuang Sun, Shuhong Li, Xiaohua Zeng, Lu Gan

Published online: 31 March 2022

PDF Pages: 362 Full Text (44020) Reporting Checklist Data Sharing Statement COI Form Open Access

Original Article

Clinical characteristics of recovered COVID-19 patients with re-detectable positive RNA test

Jianghong An, Xuejiao Liao, Tongyang Xiao, Shen Qian, Jing Yuan, Haocheng Ye, Furong Qi, Chengguang Shen, Lifei Wang, Yang Liu, Xiaoya Cheng, Na Li, Qingxian Cai, Fang Wang, Jun Chen, Guojun Li, Qiu’e Cai, Yingxia Liu, Yunfang Wang, Feng Zhang, Yang Fu, Qing He, Xiaohua Tan, Lei Liu, Zheng Zhang

Published online: 15 September 2020

PDF Pages: 1084 Full Text (43913) Reporting Checklist Data Sharing Statement COI Form Open Access

Original Article

Endometrial cavity fluid is associated with deleterious pregnancy outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection: a retrospective cohort study

Wen-Xiu Zhang, Lian-Bao Cao, Ying Zhao, Jing Li, Bo-Feng Li, Jia-Nan Lv, Lei Yan, Jin-Long Ma

Published online: 15 January 2021

PDF Pages: 9 Full Text (41812) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Review Article

Morbidity and mortality associated with obesity

Mahmoud Abdelaal, Carel W. le Roux, Neil G. Docherty

Published online: 14 April 2017

PDF Pages: 161 Full Text (40830) Open Access

Review Article

The basics of respiratory mechanics: ventilator-derived parameters

Pedro Leme Silva, Patricia R. M. Rocco

Published online: 15 October 2018

PDF Pages: 376 Full Text (40711) Open Access

Helicobacter Pylori

Diagnosis of Helicobacter pylori using the rapid urease test

Takahiro Uotani, David Y. Graham

Published online: 12 January 2015

PDF Pages: 9 Full Text (39845) Open Access

Review Article

A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management

Zhi Zheng, Yi-Xuan Ding, Yuan-Xu Qu, Feng Cao, Fei Li

Published online: 15 January 2021

PDF Pages: 69 Full Text (39072) Reporting Checklist COI Form Open Access

Big-data Clinical Trial Column

Model building strategy for logistic regression: purposeful selection

Zhongheng Zhang

Published online: 25 March 2016

PDF Pages: 111 Full Text (38385) Open Access

Review Articles

The physiological roles of secretin and its receptor

Syeda Afroze, Fanyin Meng, Kendal Jensen, Kelly McDaniel, Kinan Rahal, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Shannon S. Glaser

Published online: 06 October 2013

PDF Pages: 29 Full Text (37263) Open Access

Original Article

FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ERα/cyclin D1/Rb axis

Lu Xu, Ji-Ming Shen, Jing-Lei Qu, Na Song, Xiao-Fang Che, Ke-Zuo Hou, Jing Shi, Lei Zhao, Sha Shi, Yun-Peng Liu, Xiu-Juan Qu, Yue-E Teng

Published online: 05 February 2021

PDF Pages: 258 Full Text (36236) Reporting Checklist Peer Review File COI Form Open Access

Review Articles

Effect of high fat-diet and obesity on gastrointestinal motility

Mazen Al Mushref, Shanthi Srinivasan

Published online: 09 June 2013

PDF Pages: 14 Full Text (35343) Open Access

Review Article on Medical Artificial Intelligent Research

A review of the application of deep learning in medical image classification and segmentation

Lei Cai, Jingyang Gao, Di Zhao

Published online: 15 June 2020

PDF Pages: 713 Full Text (34838) COI Form Open Access

Review Article

Insulin autoimmune syndrome: from diagnosis to clinical management

Simona Censi, Caterina Mian, Corrado Betterle

Published online: 14 September 2018

PDF Pages: 335 Full Text (34166) Open Access

Review Article

Post-stroke cognitive impairment: epidemiology, mechanisms and management

Jia-Hao Sun, Lan Tan, Jin-Tai Yu

Published online: 26 August 2014

PDF Pages: 80 Full Text (33672) Open Access

Original Article

A bibliometric analysis using VOSviewer of publications on COVID-19

Yuetian Yu, Yujie Li, Zhongheng Zhang, Zhichun Gu, Han Zhong, Qiongfang Zha, Luyu Yang, Cheng Zhu, Erzhen Chen

Published online: 14 July 2020

PDF Pages: 816 Full Text (33643) COI Form Open Access

Review Article

Hemorrhagic transformation after cerebral infarction: current concepts and challenges

Jie Zhang, Yi Yang, Huijie Sun, Yingqi Xing

Published online: 26 August 2014

PDF Pages: 81 Full Text (33046) Open Access

Case Report

An unusual presentation of acute deep vein thrombosis after the Moderna COVID-19 vaccine—a case report

Chandur Bhan, Nimarta Bheesham, Fnu Shakuntulla, Monica Sharma, Chenyu Sun, Mitchell Weinstein

Published online: 31 October 2021

PDF Pages: 1605 Full Text (32335) Reporting Checklist COI Form Open Access

Review Article on Hemodynamic Monitoring in Critically Ill Patients

Vasopressors in septic shock: which, when, and how much?

Rui Shi, Olfa Hamzaoui, Nello De Vita, Xavier Monnet, Jean-Louis Teboul

Published online: 28 June 2020

PDF Pages: 794 Full Text (32186) COI Form Open Access

Review Article

Treating the host response to emerging virus diseases: lessons learned from sepsis, pneumonia, influenza and Ebola

David S. Fedson

Published online: 18 November 2016

PDF Pages: 421 Full Text (31274) Open Access

Review Article on Cardiopulmonary Interactions

Heart-lung interactions during mechanical ventilation: the basics

Syed S. Mahmood, Michael R. Pinsky

Published online: 27 September 2018

PDF Pages: 349 Full Text (30781) Open Access

Original Article

Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017

Aimin Wu, Lyn March, Xuanqi Zheng, Jinfeng Huang, Xiangyang Wang, Jie Zhao, Fiona M. Blyth, Emma Smith, Rachelle Buchbinder, Damian Hoy

Published online: 31 March 2020

PDF Pages: 299 Full Text (30649) Open Access

Consensus

Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition)

Laishuan Wang, Yuan Shi, Tiantian Xiao, Jianhua Fu, Xing Feng, Dezhi Mu, Qi Feng, Mingyan Hei, Xiaojing Hu, Zhankui Li, Guoping Lu, Zezhong Tang, Yajuan Wang, Chuanqing Wang, Shiwen Xia, Jianqing Xu, Yujia Yang, Jie Yang, Mei Zeng, Jun Zheng, Wei Zhou, Xiaoyu Zhou, Xiaoguang Zhou, Lizhong Du, Shoo K. Lee, Wenhao Zhou, on behalf of the Working Committee on Perinatal, and Neonatal Management for the Prevention and Control of the 2019 Novel Coronavirus Infection

Published online: 13 February 2020

PDF Pages: 47 Full Text (30028) Open Access

Review Article on Innovations and Technology in Surgery

Surgical applications of three-dimensional printing: a review of the current literature & how to get started

Don Hoang, David Perrault, Milan Stevanovic, Alidad Ghiassi

Published online: 19 December 2016

PDF Pages: 456 Full Text (28295) Open Access

Review Article on Heart Failure Update and Advances in 2021

Management of left ventricular thrombus: a narrative review

Jose B. Cruz Rodriguez, Kazue Okajima, Barry H. Greenberg

Published online: 30 March 2021

PDF Pages: 520 Full Text (27772) Reporting Checklist COI Form Open Access

Viewpoint

Which clinical significance has automatic detection of very low levels of nucleated red blood cells in the peripheral blood?

Sabrina Buoro, Barbara Manenti, Michela Seghezzi

Published online: 14 June 2016

PDF Pages: 230 Full Text (27254) Open Access

Surgical Technique

Anatomy essentials for laparoscopic inguinal hernia repair

Xue-Fei Yang, Jia-Lin Liu

Published online: 15 October 2016

PDF Pages: 372 Full Text (26941) Open Access

Review Article

Propensity score matching with R: conventional methods and new features

Qin-Yu Zhao, Jing-Chao Luo, Ying Su, Yi-Jie Zhang, Guo-Wei Tu, Zhe Luo

Published online: 15 May 2021

PDF Pages: 812 Full Text (26770) COI Form Open Access

Review Article

Dietary, non-microbial intervention to prevent Helicobacter pylori-associated gastric diseases

Young-Min Han, Jong-Min Park, Migyeong Jeong, Jun-Hwan Yoo, Won-Hee Kim, Seok-Pyo Shin, Weon-Jin Ko, Ki-Baik Hahm

Published online: 16 June 2015

PDF Pages: 122 Full Text (26513) Open Access

Big-data Clinical Trial Column

Parametric regression model for survival data: Weibull regression model as an example

Zhongheng Zhang

Published online: 29 December 2016

PDF Pages: 484 Full Text (26462) Open Access

Review Article

Impact of metformin on reproductive tissues: an overview from gametogenesis to gestation

Michael J. Bertoldo, Melanie Faure, Joelle Dupont, Pascal Froment

Published online: 27 June 2014

PDF Pages: 55 Full Text (26340) Open Access

Helicobacter Pylori

Diagnosis of Helicobacter pylori by invasive test: histology

Ju Yup Lee, Nayoung Kim

Published online: 12 January 2015

PDF Pages: 10 Full Text (25644) Open Access

Original Article on Transgender Surgery

Guiding the conversation—types of regret after gender-affirming surgery and their associated etiologies

Sasha Karan Narayan, Rayisa Hontscharuk, Sara Danker, Jess Guerriero, Angela Carter, Gaines Blasdel, Rachel Bluebond-Langner, Randi Ettner, Asa Radix, Loren Schechter, Jens Urs Berli

Published online: 15 April 2021

PDF Pages: 605 Full Text (25588) Reporting Checklist Data Sharing Statement COI Form Open Access

Original Article

Risk factors for uroseptic shock in hospitalized patients aged over 80 years with urinary tract infection

Chih-Yen Hsiao, Tsung-Hsien Chen, Yi-Chien Lee, Meng-Chang Hsiao, Peir-Haur Hung, Ming-Cheng Wang

Published online: 16 April 2020

PDF Pages: 477 Full Text (25329) COI Form Open Access

Theme Section: Pneumothorax

Pneumothorax as a complication of central venous catheter insertion

Nikolaos Tsotsolis, Katerina Tsirgogianni, Ioannis Kioumis, Georgia Pitsiou, Sofia Baka, Antonis Papaiwannou, Anastasia Karavergou, Aggeliki Rapti, Georgia Trakada, Nikolaos Katsikogiannis, Kosmas Tsakiridis, Ilias Karapantzos, Chrysanthi Karapantzou, Nikos Barbetakis, Athanasios Zissimopoulos, Ivan Kuhajda, Dejan Andjelkovic, Konstantinos Zarogoulidis, Paul Zarogoulidis

Published online: 10 March 2015

PDF Pages: 40 Full Text (25233) Open Access

Original Article

Chest CT imaging features and severity scores as biomarkers for prognostic prediction in patients with COVID-19

Shuchang Zhou, Chengyang Chen, Yiqi Hu, Wenzhi Lv, Tao Ai, Liming Xia

Published online: 15 November 2020

PDF Pages: 1449 Full Text (24924) Reporting Checklist Data Sharing Statement Peer Review File COI Form Open Access

Review Article

A narrative review of gallbladder adenomyomatosis: what we need to know

Kit-Fai Lee, Esther H. Y. Hung, Howard H. W. Leung, Paul B. S. Lai

Published online: 15 December 2020

PDF Pages: 1600 Full Text (24868) Reporting Checklist Peer Review File COI Form Open Access

Original Article

TRPC6 ameliorates renal ischemic reperfusion injury by inducing Zn²⁺ influx and activating autophagy to resist necrosis

Youmin Pu, Hongwen Zhao, Bingbing Shen, Qiang Zhou, Pan Xie, Xiongfei Wu

Published online: 14 March 2022

PDF Pages: 249 Full Text (24757) Reporting Checklist Data Sharing Statement COI Form Open Access

Review Articles

The fetal liver as cell source for the regenerative medicine of liver and pancreas

Rossella Semeraro, Vincenzo Cardinale, Guido Carpino, Raffaele Gentile, Cristina Napoli, Rosanna Venere, Manuela Gatto, Roberto Brunelli, Eugenio Gaudio, Domenico Alvaro

Published online: 09 June 2013

PDF Pages: 13 Full Text (24611) Open Access

Review Articles on Treatment for Hepatitis B

Diagnosis of hepatitis B

Jeong Eun Song, Do Young Kim

Published online: 27 September 2016

PDF Pages: 338 Full Text (24415) Open Access