Vol 12, No 2 (April 22, 2024): Annals of Translational Medicine

The Integral Theory—paradigm, not hypothesis

The integral theory paradigm in practice—addressing a major health crisis in bladder/bowel/pain management

Structural, functional, and dysfunctional pelvic anatomy

A brief physiology and pathophysiology of the bladder

A brief physiology and pathophysiology of the anorectum based on the Integral Theory paradigm

Chronic pelvic pain of “unknown origin” in the female

A practical ligament-based diagnostic system for cure of pelvic symptoms and prolapse

Principles of surgery according to the Integral Theory Paradigm (ITP)

Simulated operations (SOs) apply mechanical support to structures to confirm symptom causation

Interstitial cystitis/bladder pain syndrome: when part of the posterior fornix syndrome is potentially curable surgically

Further developments of pubourethral ligament surgery for stress urinary incontinence

Descending perineal syndrome cure by deep transversus perinei ligament repair: surgical options

Tethered vagina syndrome: massive urine loss caused by bladder neck scarring cured by skin graft

Underactive bladder, Fowler’s syndrome are potentially curable by uterosacral ligament repair

Tension-free artisan tape: a low-cost option for cure of pelvic organ prolapse and stress incontinence

Wide-bore polyester sutures may create sufficient collagen for cure of prolapse/incontinence: a work in progress

Peripheral muscle force balance/imbalance in neurological binary control of bladder function and dysfunction

Squatting-based exercises cure bedwetting in children and improve pain and bladder symptoms in premenopausal women

A comparison of native vaginal and ligament surgery for cure of pelvic organ prolapse and overactive bladder

Pubourethral and uterosacral male analogues suggest parallel male/female pelvic anatomy and symptom pathogenesis